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Predictors of 12-week remission in a nationwide cohort of people with depressive disorders: the CRESCEND study

Authors
Kim, Jae-MinKim, Sung-WanStewart, RobertKim, Seon-YoungYoon, Jin-SangJung, Sung-WonLee, Min-SooYim, Hyeon-WooJun, Tae-Youn
Issue Date
1월-2011
Publisher
WILEY
Keywords
depression; remission; anxiety; parasuicide; Korea
Citation
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, v.26, no.1, pp.41 - 50
Indexed
SCIE
SCOPUS
Journal Title
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
Volume
26
Number
1
Start Page
41
End Page
50
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/113337
DOI
10.1002/hup.1168
ISSN
0885-6222
Abstract
Objective To estimate the 12-week remission rate of patients with depressive disorders and predictors of this in a naturalistic clinical setting in South Korea. Methods For people with DSM-IV depressive disorders about to receive treatment at 18 hospitals, data on sociodemographic and health status were obtained. A free choice of clinical interventions was allowed and naturalistic follow-up took place at 1, 2, 4, 8, and 12 weeks later. Remission was defined as a Hamilton Depression Rating Scale score of <= 7 sustained to 12 weeks or last follow-up, if earlier. Results For 723 participants, the 12-week remission rate was 31.4%. Remission was more likely in women, and in patients without a prior history of suicide attempt, and those with lower baseline anxiety. Conclusions Remission associated with unrestricted clinical interventions was comparable to STAR*D estimates for citalopram alone. Comorbid anxiety and previous suicide attempt were markers of worse outcome. Copyright (C) 2011 John Wiley & Sons, Ltd.
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