The effect of immobilization of heparin and bone morphogenic protein-2 (BMP-2) to titanium surfaces on inflammation and osteoblast function
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Song, Sang-Hun | - |
dc.contributor.author | Yun, Young Pil | - |
dc.contributor.author | Choi, Byung-Joon | - |
dc.contributor.author | Kwon, Il Keun | - |
dc.contributor.author | Bae, Min Soo | - |
dc.contributor.author | Moon, Ho-Jin | - |
dc.contributor.author | Kwon, Yong-Dae | - |
dc.date.accessioned | 2021-09-07T16:29:39Z | - |
dc.date.available | 2021-09-07T16:29:39Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/113351 | - |
dc.description.abstract | The aim of this study was to investigate biologic function of bone morphorgenic protein-2 (rhBMP-2) immobilized on the heparin-grafted Ti surface Ti surfaces were first modified by 3-amino-propyltriethoxysilane (ATPES) followed by grafting of heparin BMP-2 was then immobilized on the heparin-grafted Ti surfaces Pristine Ti and functionalized Ti surfaces were characterized by X-ray photoelectron spectroscopy (XPS) measurement of water contact angles and protein adsorption The biological activity of MG-63 cells on pristine and functionalized Ti surfaces was investigated by cell proliferation assays measurement of alkaline phosphate (ALP) activity and determination of calcium deposition Anti-inflammatory effects were assessed by RT-PCR to measure the transcript levels of IL-6 and TNF-alpha XPS revealed that heparin and BMP-2 were successfully grafted and immobilized on the Ti surfaces respectively In addition Ti surfaces with BMP-2 immobilized were more hydrophilic than pristine Ti Furthermore BMP-2 immobilized Ti promoted significantly higher ALP activity and calcium deposition by MG-63 cells than pristine Ti The inflammatory response was also decreased when cells were grown on heparin-grafted BMP-2-immobilized Ti surfaces The results of this study suggest that by grafting heparin and immobilizing BMP-2 on Ti surfaces inflammation can be inhibited and osteoblast function promoted (C) 2010 Elsevier Ltd All rights reserved | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | MESENCHYMAL STEM-CELLS | - |
dc.subject | LOW-MOLECULAR-WEIGHT | - |
dc.subject | ACID-BASED HYDROGEL | - |
dc.subject | ARTICULAR-CARTILAGE | - |
dc.subject | SPINE FUSION | - |
dc.subject | KAPPA-B | - |
dc.subject | DEFECTS | - |
dc.subject | DELIVERY | - |
dc.subject | ADHESION | - |
dc.subject | RHBMP-2 | - |
dc.title | The effect of immobilization of heparin and bone morphogenic protein-2 (BMP-2) to titanium surfaces on inflammation and osteoblast function | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sung Eun | - |
dc.contributor.affiliatedAuthor | Yun, Young Pil | - |
dc.identifier.doi | 10.1016/j.biomaterials.2010.09.008 | - |
dc.identifier.scopusid | 2-s2.0-78449243961 | - |
dc.identifier.wosid | 000285401500005 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.32, no.2, pp.366 - 373 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 32 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 366 | - |
dc.citation.endPage | 373 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | LOW-MOLECULAR-WEIGHT | - |
dc.subject.keywordPlus | ACID-BASED HYDROGEL | - |
dc.subject.keywordPlus | ARTICULAR-CARTILAGE | - |
dc.subject.keywordPlus | SPINE FUSION | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | DEFECTS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | RHBMP-2 | - |
dc.subject.keywordAuthor | Titanium | - |
dc.subject.keywordAuthor | Heparin | - |
dc.subject.keywordAuthor | Bone morphogenic protein 2 (BMP 2) | - |
dc.subject.keywordAuthor | Osteoblasts | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Peri implantitis | - |
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