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Identification of Cyclicsulfonamide Derivatives with an Acetamide Group as 11 beta-Hydroxysteroid Dehydrogenase 1 Inhibitors

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dc.contributor.authorKim, Se Hoan-
dc.contributor.authorKwon, Sung Wook-
dc.contributor.authorChu, So Young-
dc.contributor.authorLee, Jae Hong-
dc.contributor.authorNarsaiah, Banda-
dc.contributor.authorKim, Chi Hyun-
dc.contributor.authorKang, Seung Kyu-
dc.contributor.authorKang, Nam Sook-
dc.contributor.authorDal Rhee, Sang-
dc.contributor.authorBae, Myung Ae-
dc.contributor.authorAhn, Sung Hoon-
dc.contributor.authorHa, Duck Chan-
dc.contributor.authorKim, Ki Young-
dc.contributor.authorAhn, Jin Hee-
dc.date.accessioned2021-09-07T16:31:59Z-
dc.date.available2021-09-07T16:31:59Z-
dc.date.created2021-06-14-
dc.date.issued2011-01-
dc.identifier.issn0009-2363-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/113364-
dc.description.abstractIn the continuation of our 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor research, cyclic sulfonamide derivatives with an acetamide group at the 2-position were synthesized and evaluated for their abilities to inhibit 11 beta-HSD1 Among this series, Compound 34 showed good in vitro activity toward human 11 beta-HSD1, selectivity against 11 beta-HSD2, microsomal stability, good pharmacokinetic and safety profiles human ether-a-go-go related gene (hERG and cytochrome P450 (CYP)) Also, a docking study explained the activity difference between human and mouse 11 beta-HSD1-
dc.languageEnglish-
dc.language.isoen-
dc.publisherPHARMACEUTICAL SOC JAPAN-
dc.subjectSELECTIVE INHIBITORS-
dc.subjectMETABOLIC SYNDROME-
dc.subjectVISCERAL OBESITY-
dc.subjectTYPE-1-
dc.subjectMICE-
dc.subjectDISCOVERY-
dc.subject11-BETA-HSD1-
dc.subjectOPTIMIZATION-
dc.subjectPOTENT-
dc.titleIdentification of Cyclicsulfonamide Derivatives with an Acetamide Group as 11 beta-Hydroxysteroid Dehydrogenase 1 Inhibitors-
dc.typeArticle-
dc.contributor.affiliatedAuthorHa, Duck Chan-
dc.identifier.doi10.1248/cpb.59.46-
dc.identifier.scopusid2-s2.0-78650810717-
dc.identifier.wosid000285696800006-
dc.identifier.bibliographicCitationCHEMICAL & PHARMACEUTICAL BULLETIN, v.59, no.1, pp.46 - 52-
dc.relation.isPartOfCHEMICAL & PHARMACEUTICAL BULLETIN-
dc.citation.titleCHEMICAL & PHARMACEUTICAL BULLETIN-
dc.citation.volume59-
dc.citation.number1-
dc.citation.startPage46-
dc.citation.endPage52-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusSELECTIVE INHIBITORS-
dc.subject.keywordPlusMETABOLIC SYNDROME-
dc.subject.keywordPlusVISCERAL OBESITY-
dc.subject.keywordPlusTYPE-1-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusDISCOVERY-
dc.subject.keywordPlus11-BETA-HSD1-
dc.subject.keywordPlusOPTIMIZATION-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordAuthordiabetes anti diabetic agent-
dc.subject.keywordAuthor11 beta-hydroxysteroid dehydrogenase type 1-
dc.subject.keywordAuthorcyclic sulfonamide-
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