클론성 염색체이상을 보인 혈구포식 림프조직구증 1예A Case of Hemophagocytic Lymphohistiocytosis with Clonal Karyotype Abnormalities
- Other Titles
- A Case of Hemophagocytic Lymphohistiocytosis with Clonal Karyotype Abnormalities
- Authors
- 최계령; 김하늬; 조치현; 유병준; 김명한; 김장수; 임채승; 이갑노
- Issue Date
- 2011
- Publisher
- 대한진단검사의학회
- Keywords
- Hemophagocytic lymphohistiocytosis; Epstein-Barr virus cytomegalovirus; Chromosomal abnormality
- Citation
- Laboratory Medicine Online, v.1, no.2, pp.110 - 114
- Indexed
- KCI
OTHER
- Journal Title
- Laboratory Medicine Online
- Volume
- 1
- Number
- 2
- Start Page
- 110
- End Page
- 114
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/113713
- ISSN
- 2093-6338
- Abstract
- There have been a few reports of hemophagocytic lymphohistiocytosis (HLH) with chromosomal abnormalities. Clonal chromosomal abnormalities in HLH patients are usually found in association with hematologic malignancies and rarely with epstein-barr virus (EBV) infection. Here, we report a fatal case of HLH with clonal karyotype abnormalities. A 75-yr-old man was admitted with persistent anorexia and high fever. Laboratory data revealed pancytopenia, hypofibrinogenemia, hyperferritinemia, prolonged prothrombin time and activated partial thromboplastin time, and marked elevated level of serum transaminases. In real time-PCR using whole blood, EBV DNA was not detected but cytomegalovirus (CMV) DNA was detected.
The bone marrow aspiration smear showed hyperplasia of mature histiocytes with prominent hemophagocytosis. In chromosomal analysis of bone marrow aspirates, complex chromosomal abnormalities were found. In spite of steroid pulse therapy and antibiotic treatment, he died of disseminated intravascular coagulopathy.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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