Changes in the Histone Acetylation Patterns during the Development of the Nervous SystemChanges in the Histone Acetylation Patterns during the Development of the Nervous System
- Other Titles
- Changes in the Histone Acetylation Patterns during the Development of the Nervous System
- Authors
- 조봉기; 김현정; 김현; 선웅
- Issue Date
- 2011
- Publisher
- 한국뇌신경과학회
- Keywords
- histone acetylation; nervous system; development; neuroepithelium
- Citation
- Experimental Neurobiology, v.20, no.2, pp.81 - 84
- Indexed
- KCI
OTHER
- Journal Title
- Experimental Neurobiology
- Volume
- 20
- Number
- 2
- Start Page
- 81
- End Page
- 84
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/114009
- ISSN
- 1226-2560
- Abstract
- Epigenetic modification such as DNA methylation and histone acetylation plays essential roles in many aspects of cellular function and development of animals. There is an increasing amounts of evidence for dynamic changes in the histone acetylation of specific gene segments, but little attempt was made to examine global pattern changes in the histone acetylation in developing nervous system. In this study, we found that acetylated histone H3 and H4 immunoreactivities were relatively weak in neuroepithelial cells in the ventricular zone of developing rat cerebral cortex or chick spinal cord, compared to the immature young neurons in the cortical plate of a rat embryo or lateral motor column in chick spinal cord. On the other hand, adult neural stem cells in the dentate gyrus (DG) of rat hippocampal formation did not exhibit such diminished histone acetylation, compared to neuroblasts and mature DG neurons. These results suggest that the level of histone acetylation is highly dynamic and tightly linked to the neuronal types and the differentiation stages.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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