Radiotherapy for pituitary adenomas: long-term outcome and complications
DC Field | Value | Language |
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dc.contributor.author | 임채홍 | - |
dc.contributor.author | 양대식 | - |
dc.contributor.author | 박영제 | - |
dc.contributor.author | 윤원섭 | - |
dc.contributor.author | 이정애 | - |
dc.contributor.author | 김철용 | - |
dc.date.accessioned | 2021-09-07T18:53:55Z | - |
dc.date.available | 2021-09-07T18:53:55Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1229-8719 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/114140 | - |
dc.description.abstract | Purpose: To evaluate long-term local control rate and toxicity in patients treated with external beam radiotherapy (EBRT) for pituitary adenomas. Materials and Methods: We retrospectively reviewed the medical records of 60 patients treated with EBRT for pituitary adenoma at Korea University Medical Center from 1996 and 2006. Thirty-fi ve patients had hormone secreting tumors, 25 patients had non-secreting tumors. Fifty-seven patients had received postoperative radiotherapy (RT), and 3 had received RT alone. Median total dose was 54 Gy (range, 36 to 61.2 Gy). The defi nition of tumor progression were as follows: evidence of tumor progression on computed tomography or magnetic resonance imaging, worsening of clinical sign requiring additional operation or others,rising serum hormone level against a previously stable or falling value, and failure of controlling serum hormone level so that the hormone level had been far from optimal range until last follow-up. Age, sex, hormone secretion, tumor extension, tumor size, and radiation dose were analyzed for prognostic signifi cance in tumor control. Results: Median follow-up was 5.7 years (range, 2 to 14.4 years). The 10-year actuarial local control rates for non-secreting and secreting adenomas were 96% and 66%, respectively. In univariate analysis, hormone secretion was signifi cant prognostic factor (p = 0.042) and cavernous sinus extension was marginally signifi cant factor (p = 0.054) for adverse local control. All other factors were not signifi cant. In multivariate analysis, hormone secretion and gender were signifi cant. Fifty-three patients had mass-effect symptoms (headache, dizziness, visual disturbance, hypopituitarism, loss of consciousness, and cranial nerve palsy). A total of 17of 23 patients with headache and 27 of 34 patients with visual impairment were improved. Twenty-seven patients experienced symptoms of endocrine hypersecretion (galactorrhea, amenorrhea, irregular menstruation, decreased libido, gynecomastia,acromegaly, and Cushing’s disease). Amenorrhea was abated in 7 of 10 patients, galactorrhea in 8 of 8 patients, acromegaly in 7 of 11 patients, Cushing’s disease in 4 of 4 patients. Long-term complication was observed in 4 patients; 3 patients with cerebrovascular accident, 1 patient developed dementia. Of these patients, 3 of 4 received more than 60 Gy of irradiation. Conclusion: EBRT is highly effective in preventing recurrence and reducing mass effect of non-secreting adenoma. Effort to improve tumor control of secreting adenoma is required. Careful long-term follow-up is required when relatively high dose is applied. Modern radiosurgery or proton RT may be options to decrease late complications. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 대한방사선종양학회 | - |
dc.title | Radiotherapy for pituitary adenomas: long-term outcome and complications | - |
dc.title.alternative | Radiotherapy for pituitary adenomas: long-term outcome and complications | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 임채홍 | - |
dc.contributor.affiliatedAuthor | 윤원섭 | - |
dc.contributor.affiliatedAuthor | 김철용 | - |
dc.identifier.bibliographicCitation | Radiation oncology journal, v.29, no.3, pp.156 - 163 | - |
dc.relation.isPartOf | Radiation oncology journal | - |
dc.citation.title | Radiation oncology journal | - |
dc.citation.volume | 29 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 156 | - |
dc.citation.endPage | 163 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001595073 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Pituitary adenoma | - |
dc.subject.keywordAuthor | Radiotherapy | - |
dc.subject.keywordAuthor | Prognostic factors | - |
dc.subject.keywordAuthor | Complications | - |
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