트레드밀 운동이 도파민 투여 MPTP-파킨슨 모델 쥐의 p-JNK pathway, 해마 치상회의 GDNF 발현 및 운동기능에 미치는 영향

Abstract

Exercise is considered to improve motor function and emotional benefits in patients with Parkinson's disease. However, it is not clear if clinical improvements are due to neuronal alterations within the affected nigrostriatal region or a result from a more general effect of exercise on affect and motivation. In previous study, we found that treadmill exercise down regulate the alpha-synuclein in the brain of mouse model of Parkinson's disease. But still we don't know about the interaction effect between dopaminergic medicine(L-Dopa) and exercise. The purpose of this study was to determined the effects of treadmill exercise and dopaminergic medicine(L-Dopa) on nigrostriatal neurodegeneration in MPTP induced mouse model of Parkinson Disease. The results of this study were summarized as follows:(1) Treadmill exercise decreased synphilin expression levels in substantia nigra and striatum of MPTP-induced parkinson's disease model. (2) Treadmill exercise inhibits decrease of cell numbers in substantia nigra and striatum. (3) Treadmill exercise group's p-JNK expression level is more lower than sedentary group in subtantia nigra. This means exercise inhibits apoptosis in the brain and induce the cell survival in the brain. (4) Treadmill exercise increase GDNF expression levels in dentate gyrus rather than sedentary group. (5) Treadmill exercise increase GDNF expression levels in hippocampus rather than sedentary group. This result(increase of GDNF expression in hippocampus and dentate gyrus) means treadmill exercise profitable for the memory and learning problem also disorientation. The results of this study suggest that treadmill exercise partially prevented dopaminergic neurodegeneration in the nigrostriatal region of the Parkinson's Disease model, and this effects were may offer a potential therapeutic adjunct to current Parkinson's Disease therapies in the future.