The effect of platelet rich plasma from bone marrow aspirate with added bone morphogenetic protein-2 on the achilles tendon-bone junction in Rabbits
DC Field | Value | Language |
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dc.contributor.author | Kim, H.J. | - |
dc.contributor.author | Nam, H.-W. | - |
dc.contributor.author | Hur, C.-Y. | - |
dc.contributor.author | Park, M. | - |
dc.contributor.author | Yang, H.S. | - |
dc.contributor.author | Kim, B.-S. | - |
dc.contributor.author | Park, J.-H. | - |
dc.date.accessioned | 2021-09-07T20:30:20Z | - |
dc.date.available | 2021-09-07T20:30:20Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 2005-291x | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/114660 | - |
dc.description.abstract | Background: To determine if exogenously injected bone marrow derived platelet-rich plasma (PRP) plus bone morphogenetic protein (BMP)-2 could accelerate the healing of bone-tendon junction injuries and increase the junction holding strength during the early regeneration period. Methods: A direct injury model of the bone-tendon junction was made using an Achilles tendon-calcaneus bone junction in a rabbit. In the PRP/BMP-2/fibrin group, 0.05 mL of bone marrow derived PRP and 100 ng/mL of BMP-2 both incorporated into 0.1 mL of fibrin glue were injected into Achilles tendon-calcaneus bone junctions. The effect of the intervention was tested by comparing the results of an intervention group to a control group. The results of biomechanical testing, and histological and gross analyses were compared between the 2 groups at the following time points after surgery: 2 weeks, 4 weeks, and 8 weeks. Results: Histologic examinations showed that woven bone developed in tendon-bone junctions at 2 weeks after surgery in the PRP/BMP-2/fibrin group. Mechanical test results showed no significant difference between the PRP/BMP-2/fibrin and control groups at 2 and 4 weeks after surgery, but the mean maximal load in the PRP/BMP-2/fibrin group was significantly higher than in the control group (p < 0.05) at 8 weeks after surgery. Conclusions: Bone marrow derived PRP and BMP-2 in fibrin glue accelerated healing in a rabbit model of tendon-bone junction injury. © 2011 by The Korean Orthopaedic Association. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Korean Orthopaedic Association | - |
dc.subject | bone morphogenetic protein 2 | - |
dc.subject | fibrin glue | - |
dc.subject | achilles tendinitis | - |
dc.subject | achilles tendon | - |
dc.subject | animal experiment | - |
dc.subject | animal tissue | - |
dc.subject | article | - |
dc.subject | biomechanics | - |
dc.subject | bone development | - |
dc.subject | bone marrow biopsy | - |
dc.subject | bone regeneration | - |
dc.subject | calcaneus | - |
dc.subject | controlled study | - |
dc.subject | fracture healing | - |
dc.subject | histology | - |
dc.subject | male | - |
dc.subject | mechanical stimulation | - |
dc.subject | nonhuman | - |
dc.subject | postoperative period | - |
dc.subject | rabbit | - |
dc.subject | thrombocyte rich plasma | - |
dc.subject | weight bearing | - |
dc.title | The effect of platelet rich plasma from bone marrow aspirate with added bone morphogenetic protein-2 on the achilles tendon-bone junction in Rabbits | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, H.J. | - |
dc.contributor.affiliatedAuthor | Hur, C.-Y. | - |
dc.contributor.affiliatedAuthor | Park, J.-H. | - |
dc.identifier.doi | 10.4055/cios.2011.3.4.325 | - |
dc.identifier.scopusid | 2-s2.0-83255188688 | - |
dc.identifier.bibliographicCitation | Clinics in Orthopedic Surgery, v.3, no.4, pp.325 - 331 | - |
dc.relation.isPartOf | Clinics in Orthopedic Surgery | - |
dc.citation.title | Clinics in Orthopedic Surgery | - |
dc.citation.volume | 3 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 325 | - |
dc.citation.endPage | 331 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001900866 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.subject.keywordPlus | bone morphogenetic protein 2 | - |
dc.subject.keywordPlus | fibrin glue | - |
dc.subject.keywordPlus | achilles tendinitis | - |
dc.subject.keywordPlus | achilles tendon | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | biomechanics | - |
dc.subject.keywordPlus | bone development | - |
dc.subject.keywordPlus | bone marrow biopsy | - |
dc.subject.keywordPlus | bone regeneration | - |
dc.subject.keywordPlus | calcaneus | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | fracture healing | - |
dc.subject.keywordPlus | histology | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mechanical stimulation | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | postoperative period | - |
dc.subject.keywordPlus | rabbit | - |
dc.subject.keywordPlus | thrombocyte rich plasma | - |
dc.subject.keywordPlus | weight bearing | - |
dc.subject.keywordAuthor | Achilles tendon | - |
dc.subject.keywordAuthor | Bone marrow derived platelet rich plasma | - |
dc.subject.keywordAuthor | Bone morphogenetic protein | - |
dc.subject.keywordAuthor | Bone-tendon junction | - |
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