Influence of chitosan coating on the liposomal surface on physicochemical properties and the release profile of nanocarrier systems
- Authors
- Bang, S. H.; Hwang, I. C.; Yu, Y. M.; Kwon, H. R.; Kim, D. H.; Park, H. J.
- Issue Date
- 2011
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- phosphatidylcholine; chitosan; controlled release; self-assembly; chitosan-coated liposome; nanocarrier system
- Citation
- JOURNAL OF MICROENCAPSULATION, v.28, no.7, pp.595 - 604
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MICROENCAPSULATION
- Volume
- 28
- Number
- 7
- Start Page
- 595
- End Page
- 604
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/114864
- DOI
- 10.3109/02652048.2011.557748
- ISSN
- 0265-2048
- Abstract
- Chitosan-coated nanoliposomes containing etofenprox or alpha-cypermethrin prepared by ultrasonic homogenization maintained a size distribution in the nanometre range. Nanoliposomes were constructed using different types and concentrations of chitosan to regulate the mean size and surface charge. As the chitosan concentration (0.1-0.5%, w/v) and the degree of deacetylation increased, surface charge also increased. The encapsulation efficiency and release profile were measured by gas chromatography. Encapsulation efficiency decreased slightly as chitosan concentration increased (0.1-0.5%, w/v). As the intrinsic surface charge or concentration of the coating material increased, the release period of the entrapped core material was extended (chitosans A and B; 0.1 and 0.3%, w/v). The results indicate that diverse preparation conditions could affect the physicochemical properties and release profile of the resulting nanocarrier systems.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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