Discovery of ortho-Carborane-Conjugated Triazines as Selective Topoisomerase I/II Inhibitors
DC Field | Value | Language |
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dc.contributor.author | Nakamura, Hiroyuki | - |
dc.contributor.author | Shoji, Atsushi | - |
dc.contributor.author | Takeuchi, Ayano | - |
dc.contributor.author | Ban, Hyun Seung | - |
dc.contributor.author | Lee, Jong-Dae | - |
dc.contributor.author | Yamori, Takao | - |
dc.contributor.author | Kang, Sang Ook | - |
dc.date.accessioned | 2021-09-07T21:15:09Z | - |
dc.date.available | 2021-09-07T21:15:09Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0004-9425 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/114866 | - |
dc.description.abstract | The cell growth inhibition profile of 2,4-(2-methyl-ortho-carboranyl)-4-(dimethylamino)-1,3,5-triazine (TAZ-6) was found to be similar to that of ICRF-193, a topoisomerase II inhibitor, as revealed by COMPARE analysis (correlation coefficient (r) = 0.724). Various mono-and di-ortho-carborane-substituted 1,3,5-triazines were synthesized based on the structure of TAZ-6 and tested for their ability to inhibit cell growth and the activities of topoisomerases I and II. Among the compounds synthesized, 3c, 4c, and 4f completely inhibited topoisomerase I activity without affecting topoisomerase II activity, whereas 3a and 3d completely inhibited topoisomerase II activity without affecting topoisomerase I activity, at 100 mu M. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CSIRO PUBLISHING | - |
dc.subject | NEUTRON-CAPTURE THERAPY | - |
dc.subject | TUMOR-CELL-LINES | - |
dc.subject | DNA TOPOISOMERASES | - |
dc.subject | 2,4,6-TRISUBSTITUTED TRIAZINES | - |
dc.subject | ANTITUMOR-ACTIVITY | - |
dc.subject | I INHIBITORS | - |
dc.subject | DERIVATIVES | - |
dc.subject | DRUG | - |
dc.subject | HEXAMETHYLMELAMINE | - |
dc.subject | CAMPTOTHECINS | - |
dc.title | Discovery of ortho-Carborane-Conjugated Triazines as Selective Topoisomerase I/II Inhibitors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Sang Ook | - |
dc.identifier.doi | 10.1071/CH11295 | - |
dc.identifier.wosid | 000297064200004 | - |
dc.identifier.bibliographicCitation | AUSTRALIAN JOURNAL OF CHEMISTRY, v.64, no.11, pp.1430 - 1437 | - |
dc.relation.isPartOf | AUSTRALIAN JOURNAL OF CHEMISTRY | - |
dc.citation.title | AUSTRALIAN JOURNAL OF CHEMISTRY | - |
dc.citation.volume | 64 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1430 | - |
dc.citation.endPage | 1437 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | NEUTRON-CAPTURE THERAPY | - |
dc.subject.keywordPlus | TUMOR-CELL-LINES | - |
dc.subject.keywordPlus | DNA TOPOISOMERASES | - |
dc.subject.keywordPlus | 2,4,6-TRISUBSTITUTED TRIAZINES | - |
dc.subject.keywordPlus | ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | I INHIBITORS | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | HEXAMETHYLMELAMINE | - |
dc.subject.keywordPlus | CAMPTOTHECINS | - |
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