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Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages

Authors
Lim, Eun-KyungJang, EunjiKim, BongjuneChoi, JihyeLee, KwangyeolSuh, Jin-SuckHuh, Yong-MinHaam, Seungjoo
Issue Date
2011
Publisher
ROYAL SOC CHEMISTRY
Citation
JOURNAL OF MATERIALS CHEMISTRY, v.21, no.33, pp.12473 - 12478
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF MATERIALS CHEMISTRY
Volume
21
Number
33
Start Page
12473
End Page
12478
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/114914
DOI
10.1039/c1jm10764j
ISSN
0959-9428
Abstract
We fabricated dextran-coated magnetic nanoclusters (Dex-MNCs) for targeted magnetic resonance (MR) imaging of inflammatory macrophages. Dex-MNCs were prepared through encapsulation of hydrophobic magnetic nanocrystals (MNCs) by pyrenyl dextran in order that MNCs could achieve increased colloidal stability in aqueous phase as well as strongly interact with macrophages. Dex-MNCs exhibited biocompatibility and sufficient targeting efficiency against macrophages with strengthened MR contrast effect from in vitro/in vivo studies. Considering these results, we confirmed that Dex-MNCs could accurately detect inflammatory macrophage via MR imaging.
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