Microinflammation in Hemodialysis Patients Is Associated with Increased CD14(+)CD16(+) Pro-Inflammatory Monocytes: Possible Modification by On-Line Hemodiafiltration
- Authors
- Kim, Hye Won; Yang, Ha-Na; Kim, Myung Gyu; Choi, Hye Min; Jo, Sang-Kyung; Cho, Won Yong; Kim, Hyoung Kyu
- Issue Date
- 2011
- Publisher
- KARGER
- Keywords
- Chronic inflammation; Hemodialysis; On-line hemodiafiltration; Monocytes; Tumor necrosis factor
- Citation
- BLOOD PURIFICATION, v.31, no.4, pp.281 - 288
- Indexed
- SCIE
SCOPUS
- Journal Title
- BLOOD PURIFICATION
- Volume
- 31
- Number
- 4
- Start Page
- 281
- End Page
- 288
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/114946
- DOI
- 10.1159/000321889
- ISSN
- 0253-5068
- Abstract
- Background: An increased percentage of pro-inflammatory CD14(+)CD16(+) monocytes might contribute to inflammation in hemodialysis (HD) patients. The purpose of the study was to evaluate the possible contribution of pro-inflammatory monocytes to inflammation in HD patients and also to evaluate the effect of on-line hemodiafiltration (HDF). Methods: Flow cytometric detection of monocytes in patients undergoing HD, on-line HDF and healthy controls as well as plasma cytokines and cytokine mRNA measurement were performed. Results: Percent pro-inflammatory monocytes, plasma cytokines and cytokine mRNA significantly increased in HD patients. Intracellular cytokine staining showed pro-inflammatory monocytes were the predominant source of tumor necrosis factor-alpha. Percent pro-inflammatory monocytes positively correlated with plasma inflammatory cytokines. Percent pro-inflammatory monocytes, plasma cytokines and cytokine mRNA significantly decreased in on-line HDF patients. Conclusion: Increased pro-inflammatory monocytes are likely to contribute to inflammation in HD patients, and beneficial effect of on-line HDF might be partially mediated by modulating the inflammatory response. Copyright (C) 2011 S. Karger AG, Basel
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