4-O-Methylhonokiol Attenuated Memory Impairment Through Modulation of Oxidative Damage of Enzymes Involving Amyloid-beta Generation and Accumulation in a Mouse Model of Alzheimer's Disease
DC Field | Value | Language |
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dc.contributor.author | Choi, Im Seop | - |
dc.contributor.author | Lee, Young-Jung | - |
dc.contributor.author | Choi, Dong-Young | - |
dc.contributor.author | Lee, Yong Kyung | - |
dc.contributor.author | Lee, Yeun Hee | - |
dc.contributor.author | Kim, Ki Ho | - |
dc.contributor.author | Kim, Young Heui | - |
dc.contributor.author | Jeon, Young Ho | - |
dc.contributor.author | Kim, Eun Hee | - |
dc.contributor.author | Han, Sang Bae | - |
dc.contributor.author | Jung, Jae Kyung | - |
dc.contributor.author | Yun, Yeo Pyo | - |
dc.contributor.author | Oh, Ki-Wan | - |
dc.contributor.author | Hwang, Dae Youn | - |
dc.contributor.author | Hong, Jin Tae | - |
dc.date.accessioned | 2021-09-07T21:45:59Z | - |
dc.date.available | 2021-09-07T21:45:59Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/114987 | - |
dc.description.abstract | Accumulations of amyloid-beta (A beta) and oxidative damage are critical pathological mechanisms in the development of Alzheimer's disease (AD). We previously found that 4-O-methylhonokiol, a compound extracted from Magnolia officinalis, improved memory dysfunction in A beta-injected and presenilin 2 mutant mice through the reduction of accumulated A beta. To investigate mechanisms of the reduced A beta accumulation, we examined generation, degradation, efflux and aggregation of A beta in Swedish A beta PP AD model (A beta PPsw) mice pre-treated with 4-O-methylhonokiol (1.0 mg/kg) for 3 months. 4-O-methylhonokiol treatment recovered memory impairment and prevented neuronal cell death. This memory improving activity was associated with 4-O-methylhonokiol-induced reduction of A beta(1-42) accumulation in the brains of A beta PPsw mice. According to the reduction of A beta(1-42) accumulation, 4-O-methylhonkiol modulated oxidative damage sensitive enzymes. 4-O-methylhonkiol decreased expression and activity of brain beta-site A beta PP cleaving enzyme (BACE1), but increased clearance of A beta in the brain through an increase of expressions and activities of A beta degradation enzymes; insulin degrading enzyme and neprilysin. 4-O-methylhonkiol also increased expression of A beta transport molecule, low density lipoprotein receptor-related protein-1 in the brain and liver. 4-O-methylhonkiol decreased carbonyl protein and lipid peroxidation, but increased glutathione levels in the brains of A beta PPsw mice suggesting that oxidative damage of protein and lipid is critical in the impairment of those enzyme activities. 4-O-methylhonokiol treatment also prevented neuronal cell death in the A beta PPsw mousee brain through inactivation of caspase-3 and BAX. These results suggest that 4-O-methylhonokiol might prevent the development and progression of AD by reducing A beta accumulation through an increase of clearance and decrease of A beta generation via antioxidant mechanisms. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IOS PRESS | - |
dc.subject | INSULIN-DEGRADING ENZYME | - |
dc.subject | MAGNOLIA-OFFICINALIS | - |
dc.subject | PRECURSOR PROTEIN | - |
dc.subject | NEURONAL TOXICITY | - |
dc.subject | ETHANOL EXTRACT | - |
dc.subject | HONOKIOL | - |
dc.subject | STRESS | - |
dc.subject | MICE | - |
dc.subject | NEURODEGENERATION | - |
dc.subject | ACTIVATION | - |
dc.title | 4-O-Methylhonokiol Attenuated Memory Impairment Through Modulation of Oxidative Damage of Enzymes Involving Amyloid-beta Generation and Accumulation in a Mouse Model of Alzheimer's Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeon, Young Ho | - |
dc.identifier.doi | 10.3233/JAD-2011-110545 | - |
dc.identifier.scopusid | 2-s2.0-80155161305 | - |
dc.identifier.wosid | 000296570400012 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALZHEIMERS DISEASE, v.27, no.1, pp.127 - 141 | - |
dc.relation.isPartOf | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.citation.title | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.citation.volume | 27 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 127 | - |
dc.citation.endPage | 141 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | INSULIN-DEGRADING ENZYME | - |
dc.subject.keywordPlus | MAGNOLIA-OFFICINALIS | - |
dc.subject.keywordPlus | PRECURSOR PROTEIN | - |
dc.subject.keywordPlus | NEURONAL TOXICITY | - |
dc.subject.keywordPlus | ETHANOL EXTRACT | - |
dc.subject.keywordPlus | HONOKIOL | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | amyloid-beta | - |
dc.subject.keywordAuthor | A beta PPsw mouse | - |
dc.subject.keywordAuthor | 4-O-methylhonokiol | - |
dc.subject.keywordAuthor | oxidative stress | - |
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