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Rationally designed fluorescence 'turn-on' sensor for Cu2+
- Authors
- Ko, Kyoung Chul; Wu, Jia-Sheng; Kim, Hyun Jung; Kwon, Pil Seung; Kim, Jong Wan; Bartsch, Richard A.; Lee, Jin Yong; Kim, Jong Seung
- Issue Date
- 2011
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.47, no.11, pp.3165 - 3167
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 47
- Number
- 11
- Start Page
- 3165
- End Page
- 3167
- ISSN
- 1359-7345
- Abstract
- A rationally designed, coumarin-based fluorescent sensor imino-coumarin (IC) displays high selectivity for Cu2+ over a variety of competing metal ions in aqueous solution with a significant fluorescence increase. DFT/TDDFT calculations support that the fluorescence 'turn-on' of IC originates from blocking the electron transfer of the nitrogen lone pair upon complexation with Cu2+. IC was successfully applied tomicroscopic imaging for detection of Cu2+ in LLC-MK2 cells (in vitro) and several living organs (in vivo).
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