Expression of Hepatocyte Growth Factor/c-met by RT-PCR in Meningiomas
DC Field | Value | Language |
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dc.contributor.author | Kim, Na Rae | - |
dc.contributor.author | Chae, Yang Seok | - |
dc.contributor.author | Lim, Weon Jeong | - |
dc.contributor.author | Cho, Seong Jin | - |
dc.date.accessioned | 2021-09-07T21:55:10Z | - |
dc.date.available | 2021-09-07T21:55:10Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115037 | - |
dc.description.abstract | Background: Hepatocyte growth factor (HGF) is a potent mitogenic cytokine. C-met protein, which is known to be the HGF receptor has transmembrane tyrosine kinase activity and is encoded by the c-met oncogene. The HGF/c-met signaling pathway may play various roles in the carcinogenesis of various organs. Methods: We examined HGF and c-met mRNA expression by utilizing reverse transcription polymerase chain reaction on 40 surgically resected intracranial meningiomas (25 benign, 10 atypical, and 5 anaplastic cases). Results: An HGF overexpression was detected in 28%, 50%, and 80% of the benign, atypical and anaplastic meningiomas, respectively; a high expression of HGF or the coexpression of HGF/c-met was detected in the high grade meningiomas (the atypical and anaplastic cases, p = 0.046, p = 0.014). An HGF expression was statistically significant in the recurrent meningiomas (p = 0.003), and HGF expression was significantly lower than c-met mRNA expression in benign meningiomas (p = 0.034). Conclusions: There was no correlation between histologic subtypes and HGF/c-met expression. Determination of HGF expression can be used as a molecular predictor for recurrence of meningioimas. These results suggest that HGF and c-met expression in meningiomas may be associated with anaplastic progression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY PATHOLOGISTS | - |
dc.subject | FACTOR SCATTER FACTOR | - |
dc.subject | FACTOR/SCATTER FACTOR HGF/SF | - |
dc.subject | RECEPTOR C-MET | - |
dc.subject | PREDICT RECURRENCE | - |
dc.subject | OVEREXPRESSION | - |
dc.subject | MOTILITY | - |
dc.subject | GLIOMAS | - |
dc.subject | BENIGN | - |
dc.subject | POTENT | - |
dc.subject | MIB-1 | - |
dc.title | Expression of Hepatocyte Growth Factor/c-met by RT-PCR in Meningiomas | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chae, Yang Seok | - |
dc.identifier.doi | 10.4132/KoreanJPathol.2011.45.5.463 | - |
dc.identifier.scopusid | 2-s2.0-84856655644 | - |
dc.identifier.wosid | 000297157100003 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PATHOLOGY, v.45, no.5, pp.463 - 468 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PATHOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF PATHOLOGY | - |
dc.citation.volume | 45 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 463 | - |
dc.citation.endPage | 468 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001596681 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | FACTOR SCATTER FACTOR | - |
dc.subject.keywordPlus | FACTOR/SCATTER FACTOR HGF/SF | - |
dc.subject.keywordPlus | RECEPTOR C-MET | - |
dc.subject.keywordPlus | PREDICT RECURRENCE | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | MOTILITY | - |
dc.subject.keywordPlus | GLIOMAS | - |
dc.subject.keywordPlus | BENIGN | - |
dc.subject.keywordPlus | POTENT | - |
dc.subject.keywordPlus | MIB-1 | - |
dc.subject.keywordAuthor | Hepatocyte growth factor | - |
dc.subject.keywordAuthor | c-met | - |
dc.subject.keywordAuthor | Meningioma | - |
dc.subject.keywordAuthor | Neoplasm recurrence | - |
dc.subject.keywordAuthor | local | - |
dc.subject.keywordAuthor | Reverse transcription polymerase chain reaction | - |
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