Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Role of elevated pressure in TRAIL-induced apoptosis in human lung carcinoma cells

Full metadata record
DC Field Value Language
dc.contributor.authorOh, Sangnam-
dc.contributor.authorKwon, Daeho-
dc.contributor.authorLee, Hyun Jeong-
dc.contributor.authorKim, Joonhee-
dc.contributor.authorLee, Eunil-
dc.date.accessioned2021-09-07T22:23:15Z-
dc.date.available2021-09-07T22:23:15Z-
dc.date.issued2010-12-
dc.identifier.issn1360-8185-
dc.identifier.issn1573-675X-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/115181-
dc.description.abstractTNF-related apoptosis-inducing ligand (TRAIL, Apo2L) is a promising anticancer agent with high specificity for cancer cells. Many strategies have been proposed to enhance the sensitivity of cancer cells to TRAIL-mediated apoptosis, including the use of combination treatment with conventional cancer therapies. However, few reports have evaluated the effects of TRAIL in combination with mechanical stress, which can also cause apoptosis of cancer cells. In the present study, we describe a custom-designed culture system that delivers two atmospheres of elevated pressure (EP) by using compressed air, and which enhances the sensitivity of cancer cells to TRAIL-mediated apoptosis. The combination of TRAIL and EP significantly increased apoptosis of human H460 lung cancer cells more than hyperbaric normoxia or normobaric mild hyperoxia. EP-potentiating TRAIL-mediated apoptosis of H460 cells was accompanied by up-regulated death receptor 5 (DR5), activation of caspases, decreased mitochondrial membrane potential, and reactive oxygen species production. We also observed EP-induced sensitization of TRAIL-mediated apoptosis in other cancer cell types. In contrast, human normal cells showed no DNA damage or cell death when exposed to the combined treatment. In a chicken chorioallantoic membrane model, EP enhanced TRAIL-mediated apoptosis of tumors that developed from transplanted H460 cells. Collectively, EP enhanced TRAIL-induced apoptosis of human lung carcinoma cells in vitro and in vivo. These findings suggest that EP is a mechanical and physiological stimulus that might have utility as a sensitizing tool for cancer therapy.-
dc.format.extent12-
dc.language영어-
dc.language.isoENG-
dc.publisherSPRINGER-
dc.titleRole of elevated pressure in TRAIL-induced apoptosis in human lung carcinoma cells-
dc.typeArticle-
dc.publisher.location네덜란드-
dc.identifier.doi10.1007/s10495-010-0525-5-
dc.identifier.scopusid2-s2.0-78649926133-
dc.identifier.wosid000284840300011-
dc.identifier.bibliographicCitationAPOPTOSIS, v.15, no.12, pp 1517 - 1528-
dc.citation.titleAPOPTOSIS-
dc.citation.volume15-
dc.citation.number12-
dc.citation.startPage1517-
dc.citation.endPage1528-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.subject.keywordPlusHYPERBARIC-OXYGEN THERAPY-
dc.subject.keywordPlusPROSTATE-CANCER CELLS-
dc.subject.keywordPlusDEATH RECEPTORS-
dc.subject.keywordPlusVENOUS HYPERTENSION-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusSENESCENCE-
dc.subject.keywordPlusFLIP-
dc.subject.keywordPlusSENSITIZATION-
dc.subject.keywordPlusRADIOTHERAPY-
dc.subject.keywordPlusFIBROBLASTS-
dc.subject.keywordAuthorElevated pressure-
dc.subject.keywordAuthorTNF-related apoptosis-inducing ligand (TRAIL)-
dc.subject.keywordAuthorApoptosis-
dc.subject.keywordAuthorCancer therapy-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE