Benchtop fabrication of PDMS microstructures by an unconventional photolithographic method
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Chang Mo | - |
dc.contributor.author | Sim, Woo Young | - |
dc.contributor.author | Lee, Seung Hwan | - |
dc.contributor.author | Foudeh, Amir M. | - |
dc.contributor.author | Bae, Hojae | - |
dc.contributor.author | Lee, Sang-Hoon | - |
dc.contributor.author | Khademhosseini, Ali | - |
dc.date.accessioned | 2021-09-07T22:29:07Z | - |
dc.date.available | 2021-09-07T22:29:07Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 1758-5082 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115213 | - |
dc.description.abstract | Poly(dimethylsiloxane) (PDMS) microstructures have been widely used in bio-microelectromechanical systems (bio-MEMS) for various types of analytical, diagnostic and therapeutic applications. However, PDMS-based soft lithographic techniques still use conventional microfabrication processes to generate a master mold, which requires access to clean room facilities and costly equipment. With the increasing use of these systems in various fields, the development of benchtop systems for fabricating microdevices is emerging as an important challenge in their widespread use. Here we demonstrate a simple, low-cost and rapid method to fabricate PDMS microstructures by using micropatterned poly(ethylene glycol) diacrylate (PEGDA) master molds. In this method, PEGDA microstructures were patterned on a glass substrate by photolithography under ambient conditions and by using simple tools. The resulting PEGDA structures were subsequently used to generate PDMS microstructures by standard molding in a reproducible and repeatable manner. The thickness of the PEGDA microstructures was controllable from 15 to 300 mu m by using commonly available spacer materials. We also demonstrate the use of this method to fabricate microfluidic channels capable of generating concentration gradients. In addition, we fabricated PEGDA microstructures by photolithography from the light generated from commonly available laminar cell culture hood. These data suggest that this approach could be beneficial for fabricating low-cost PDMS-based microdevices in resource limited settings. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IOP PUBLISHING LTD | - |
dc.subject | GLYCOL) HYDROGEL MICROSTRUCTURES | - |
dc.subject | MICROFLUIDIC DEVICES | - |
dc.subject | PEG HYDROGELS | - |
dc.subject | LITHOGRAPHY | - |
dc.subject | COCULTURES | - |
dc.subject | CELLS | - |
dc.title | Benchtop fabrication of PDMS microstructures by an unconventional photolithographic method | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Hoon | - |
dc.identifier.doi | 10.1088/1758-5082/2/4/045001 | - |
dc.identifier.scopusid | 2-s2.0-79953015337 | - |
dc.identifier.wosid | 000285334000002 | - |
dc.identifier.bibliographicCitation | BIOFABRICATION, v.2, no.4 | - |
dc.relation.isPartOf | BIOFABRICATION | - |
dc.citation.title | BIOFABRICATION | - |
dc.citation.volume | 2 | - |
dc.citation.number | 4 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | GLYCOL) HYDROGEL MICROSTRUCTURES | - |
dc.subject.keywordPlus | MICROFLUIDIC DEVICES | - |
dc.subject.keywordPlus | PEG HYDROGELS | - |
dc.subject.keywordPlus | LITHOGRAPHY | - |
dc.subject.keywordPlus | COCULTURES | - |
dc.subject.keywordPlus | CELLS | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.