Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kyeong | - |
dc.contributor.author | Lee, Jee-Hyun | - |
dc.contributor.author | Boovanahalli, Shanthaveerappa K. | - |
dc.contributor.author | Choi, Yongseok | - |
dc.contributor.author | Choo, Soo-Jin | - |
dc.contributor.author | Yoo, Ick-dong | - |
dc.contributor.author | Kim, Dong Hee | - |
dc.contributor.author | Yun, Mi Young | - |
dc.contributor.author | Lee, Gye Won | - |
dc.contributor.author | Song, Gyu-Yong | - |
dc.date.accessioned | 2021-09-07T22:32:09Z | - |
dc.date.available | 2021-09-07T22:32:09Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115231 | - |
dc.description.abstract | We report the synthesis of a novel series of highly potent melanin inhibitors which were obtained through structural modification of an anticancer compound S-(+)-decursinol. The in vitro inhibitory potencies of the newly synthesized compounds were evaluated against alpha-MSH induced melanin production in 816 murine melanoma cells. Among the compounds evaluated, compounds 2, 3, 6b, 7a, 7b, 8a and 8b emerged as highly potent inhibitors of melanin production. Besides, these compounds demonstrated significantly low cytotoxicity. (C) 2010 Elsevier Masson SAS. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | ANGELICA-GIGAS | - |
dc.subject | TYROSINASE | - |
dc.subject | ACID | - |
dc.subject | ROOT | - |
dc.subject | DERIVATIVES | - |
dc.subject | DECURSIN | - |
dc.subject | AGENT | - |
dc.subject | MOUSE | - |
dc.title | Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Yongseok | - |
dc.identifier.doi | 10.1016/j.ejmech.2010.09.006 | - |
dc.identifier.scopusid | 2-s2.0-78649269475 | - |
dc.identifier.wosid | 000285485000003 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.45, no.12, pp.5567 - 5575 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.title | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.volume | 45 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 5567 | - |
dc.citation.endPage | 5575 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | ANGELICA-GIGAS | - |
dc.subject.keywordPlus | TYROSINASE | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | ROOT | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | DECURSIN | - |
dc.subject.keywordPlus | AGENT | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordAuthor | (+)-Decursinol | - |
dc.subject.keywordAuthor | (+)-Decursin | - |
dc.subject.keywordAuthor | (+)-Decursinol angelate | - |
dc.subject.keywordAuthor | Melanin inhibitors | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.