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Endometrial mullerian adenosarcoma after toremifene treatment in breast cancer patients: a case report

Authors
Chung, Ye WonBae, Hyo SookHan, Song I.Song, Jae YoonKim, In SunKang, Jae Seong
Issue Date
12월-2010
Publisher
KOREAN SOC GYNECOLOGY ONCOLOGY & COLPOSCOPY
Keywords
Toremifene; Tamoxifen; Mullerian adenosarcoma; Mullerian adenofibroma; Breast cancer
Citation
JOURNAL OF GYNECOLOGIC ONCOLOGY, v.21, no.4, pp.269 - 272
Indexed
SCIE
SCOPUS
KCI
OTHER
Journal Title
JOURNAL OF GYNECOLOGIC ONCOLOGY
Volume
21
Number
4
Start Page
269
End Page
272
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/115241
DOI
10.3802/jgo.2010.21.4.269
ISSN
2005-0380
Abstract
Toremifene is an anti-estrogen which has been shown to be effective in the treatment of breast cancer, and is thought to be a less uterotrophic agent than tamoxifen. The risk assessment concerning endometrial cancer has been inconclusive because of its rare use up to the mid-1990s. We report a case of an adenosarcoma, which is a very rare type of uterine malignancy, after toremifene treatment for 5 years in a breast cancer patient. After 1 year of toremifene use, the patient had a benign Mullerian adenofibroma. After an additional 4 years of toremifene treatment, the endometrial polypoid lesion was transformed into a Mullerian adenosarcoma. Although toremifene is a promising anti-estrogenic agent in the treatment of breast cancer patients, clinicians should not neglect the possibility of a uterine malignancy.
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