MRI of magnetically labeled mesenchymal stem cells in hepatic failure model
DC Field | Value | Language |
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dc.contributor.author | Son, Kyu Ri | - |
dc.contributor.author | Chung, Se Young | - |
dc.contributor.author | Kim, Hyo-Cheol | - |
dc.contributor.author | Kim, Hoe Suk | - |
dc.contributor.author | Choi, Seung Hong | - |
dc.contributor.author | Lee, Jeong Min | - |
dc.contributor.author | Moon, Woo Kyung | - |
dc.date.accessioned | 2021-09-07T22:50:04Z | - |
dc.date.available | 2021-09-07T22:50:04Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-11-28 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115307 | - |
dc.description.abstract | AIM: To track intravascularly transplanted mesenchymal stem cells (MSCs) labeled with superparamagnetic iron oxide (SPIO) by using magnetic resonance imaging (MRI) in an experimental rabbit model of hepatic failure. METHODS: Human MSCs labeled with FDA-approved SPIO particles (Feridex) were transplanted via the mes enteric vein into rabbits (n = 16) with carbon tetrachloride-induced hepatic failure. Magnetic resonance (MR) examinations were performed with a 3.0 T clinical scanner immediately before and 2 h and 1, 3, and 7 d after transplantation. Signal intensity (SI) changes on T2*-weighted MRI were measured, and correlation between MR findings and histomorphologic findings was also investigated. RESULTS: SI on T2*-weighted MRI decreased significantly in the liver 2 h after injection of human MSCs and returned gradually to the levels found before injection in 7 d. Changes in SI in the liver at 2 h, 1, 3, and 7 d were 41.87% +/- 9.63%, 10.42% +/- 4.3%, 5.12% +/- 1.9%, 3.75% +/- 1.2%, respectively (P < 0.001). Histologic analyses confirmed the presence of MSCs in the liver, localized mainly in the sinusoids in early period (2 h and 1 d) and concentrated to the border zone in late period (3 and 7 d). The number of iron-positive cells in the liver at 2 h and on 1, 3 and 7 d after transplantation was 29.2 +/- 4.8, 10.1 +/- 3.7, 6.7 +/- 2.2, and 5.8 +/- 2.1, respectively (P = 0.013). CONCLUSION: Intravascularly injected SPIO-labeled MSCs in an experimental rabbit model of hepatic failure can be detected and followed with MRI. (C) 2010 Baishideng. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BAISHIDENG PUBLISHING GROUP INC | - |
dc.subject | IN-VIVO | - |
dc.subject | BONE-MARROW | - |
dc.subject | OVAL CELLS | - |
dc.subject | RAT-LIVER | - |
dc.subject | TRACKING | - |
dc.subject | MIGRATION | - |
dc.subject | DIFFERENTIATE | - |
dc.subject | HEPATOCYTES | - |
dc.title | MRI of magnetically labeled mesenchymal stem cells in hepatic failure model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Son, Kyu Ri | - |
dc.identifier.doi | 10.3748/wjg.v16.i44.5611 | - |
dc.identifier.scopusid | 2-s2.0-78649702032 | - |
dc.identifier.wosid | 000284989700011 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, v.16, no.44, pp.5611 - 5615 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.title | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.volume | 16 | - |
dc.citation.number | 44 | - |
dc.citation.startPage | 5611 | - |
dc.citation.endPage | 5615 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | OVAL CELLS | - |
dc.subject.keywordPlus | RAT-LIVER | - |
dc.subject.keywordPlus | TRACKING | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | DIFFERENTIATE | - |
dc.subject.keywordPlus | HEPATOCYTES | - |
dc.subject.keywordAuthor | Stem cell | - |
dc.subject.keywordAuthor | Liver failure | - |
dc.subject.keywordAuthor | Magnetic resonance | - |
dc.subject.keywordAuthor | Nanoparticle | - |
dc.subject.keywordAuthor | Transplantation | - |
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