In vivo tumor suppression activity by T cell-specific T-bet restoration
DC Field | Value | Language |
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dc.contributor.author | Lee, Kihyun | - |
dc.contributor.author | Min, Hyun Jung | - |
dc.contributor.author | Jang, Eun Jung | - |
dc.contributor.author | Hong, Jeong-Ho | - |
dc.contributor.author | Hwang, Eun Sook | - |
dc.date.accessioned | 2021-09-07T23:00:08Z | - |
dc.date.available | 2021-09-07T23:00:08Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-11-01 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115345 | - |
dc.description.abstract | T-box-containing protein expressed in T cells (T-bet) is a master transcription factor for the development of interferon (IFN) gamma-producing T helper 1 (Th1) cells, and also functions in other immune cells including natural killer (NK), cytotoxic T lymphocytes and dendritic cells. T-bet-deficient mice increased susceptibility to viral infection and tumor development due to the defective functions of immune cells. T-bet is known to play a key role in NK-mediated antimetastatic response; however, it remains to be characterized whether T-bet is essential for in vivo tumor suppression mediated by T cells. Here, we have investigated in vivo tumor suppression effect of T-bet-restored T cells using T cell-specific and inducible T-bet transgenic mice generated in a T-bet-deficient background. T-bet-null mice increased susceptibility to tumor development, whereas induction of T cell-specific T-bet expression upon melanoma cell injection substantially suppressed tumor development by inducing IFN gamma production in T cells and tumor cell apoptosis. Late induction of T-bet expression in tumor-bearing mice produced comparable amounts of IFN gamma with control and, significantly decreased tumor volume. In addition, increased melanoma lung metastasis in T-bet-deficient mice was strikingly inhibited by T-bet restoration in T cells. Intravenous injection of activated Th1 cells, not T-bet-null Th1 cells, attenuated metastatic melanoma progression, in addition, restoration of T-bet in T-bet-null Th1 cells certainly retrieved antimetastatic activity. These results suggest that T-bet expression in T cells is crucial for the control of tumor development and antimetastatic activity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | ANTITUMOR IMMUNE-RESPONSE | - |
dc.subject | IFN-GAMMA | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | CANCER IMMUNOSURVEILLANCE | - |
dc.subject | LINEAGE COMMITMENT | - |
dc.subject | LYMPHOCYTES-T | - |
dc.subject | TH1 CELLS | - |
dc.subject | METASTASIS | - |
dc.subject | ANTIGEN | - |
dc.subject | CD4 | - |
dc.title | In vivo tumor suppression activity by T cell-specific T-bet restoration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Jeong-Ho | - |
dc.identifier.doi | 10.1002/ijc.25238 | - |
dc.identifier.scopusid | 2-s2.0-77956642612 | - |
dc.identifier.wosid | 000282539600014 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CANCER, v.127, no.9, pp.2129 - 2137 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CANCER | - |
dc.citation.title | INTERNATIONAL JOURNAL OF CANCER | - |
dc.citation.volume | 127 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2129 | - |
dc.citation.endPage | 2137 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | ANTITUMOR IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | CANCER IMMUNOSURVEILLANCE | - |
dc.subject.keywordPlus | LINEAGE COMMITMENT | - |
dc.subject.keywordPlus | LYMPHOCYTES-T | - |
dc.subject.keywordPlus | TH1 CELLS | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | CD4 | - |
dc.subject.keywordAuthor | T-bet | - |
dc.subject.keywordAuthor | Th cell | - |
dc.subject.keywordAuthor | IFN gamma | - |
dc.subject.keywordAuthor | tumor development | - |
dc.subject.keywordAuthor | metastatic melanoma | - |
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