CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice
DC Field | Value | Language |
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dc.contributor.author | Kang, Young Sun | - |
dc.contributor.author | Lee, Mi Hwa | - |
dc.contributor.author | Song, Hye Kyoung | - |
dc.contributor.author | Ko, Gang Jee | - |
dc.contributor.author | Kwon, Oh Sung | - |
dc.contributor.author | Lim, Tae Kyung | - |
dc.contributor.author | Kim, Sung Hwan | - |
dc.contributor.author | Han, Sang Youb | - |
dc.contributor.author | Han, Kum Hyun | - |
dc.contributor.author | Lee, Ji Eun | - |
dc.contributor.author | Han, Jee Young | - |
dc.contributor.author | Kim, Hyoung Kyu | - |
dc.contributor.author | Cha, Dae Ryong | - |
dc.date.accessioned | 2021-09-07T23:05:13Z | - |
dc.date.available | 2021-09-07T23:05:13Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-11 | - |
dc.identifier.issn | 0085-2538 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115375 | - |
dc.description.abstract | Chemokine ligand 2 (CCL2) binds to its receptor C-C chemokine receptor 2 (CCR2), initiating tissue inflammation, and recent studies have suggested a beneficial effect of a blockade of this pathway in diabetic nephropathy. To investigate the mechanism of protection, we studied the effect of RS504393, a CCR2 antagonist, on insulin resistance and diabetic nephropathy in db/db mice. Administering this antagonist improved insulin resistance as confirmed by various biomarkers, including homeostasis model assessment index levels, plasma insulin levels, and lipid abnormalities. Mice treated with the antagonist had a significant decrease in epididymal fat mass as well as phenotypic changes of adipocytes into small differentiated forms with decreased CCL2 expression and lipid hydroperoxide levels. In addition, treatment with the CCR2 antagonist markedly decreased urinary albumin excretion, mesangial expansion, and suppressed profibrotic and proinflammatory cytokine synthesis. Furthermore, the CCR2 antagonist improved lipid metabolism, lipid hydroperoxide, cholesterol, and triglyceride contents of the kidney, and decreased urinary 8-isoprostane levels. Hence, our findings suggest that CCR2 antagonists can improve insulin resistance by modulation of the adipose tissue and restore renal function through both metabolic and anti-fibrotic effects in type 2 diabetic mice. Kidney International (2010) 78, 883-894; doi:10.1038/ki.2010.263; published online 4 August 2010 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | - |
dc.subject | DB/DB MICE | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | MACROPHAGE RECRUITMENT | - |
dc.subject | ATHEROSCLEROSIS RISK | - |
dc.subject | CHEMOKINE RECEPTORS | - |
dc.subject | HEPATIC STEATOSIS | - |
dc.subject | UP-REGULATION | - |
dc.subject | OBESITY | - |
dc.title | CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Young Sun | - |
dc.contributor.affiliatedAuthor | Ko, Gang Jee | - |
dc.contributor.affiliatedAuthor | Kim, Sung Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Kyu | - |
dc.contributor.affiliatedAuthor | Cha, Dae Ryong | - |
dc.identifier.doi | 10.1038/ki.2010.263 | - |
dc.identifier.scopusid | 2-s2.0-77958102050 | - |
dc.identifier.wosid | 000282985700009 | - |
dc.identifier.bibliographicCitation | KIDNEY INTERNATIONAL, v.78, no.9, pp.883 - 894 | - |
dc.relation.isPartOf | KIDNEY INTERNATIONAL | - |
dc.citation.title | KIDNEY INTERNATIONAL | - |
dc.citation.volume | 78 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 883 | - |
dc.citation.endPage | 894 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | - |
dc.subject.keywordPlus | DB/DB MICE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | MACROPHAGE RECRUITMENT | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS RISK | - |
dc.subject.keywordPlus | CHEMOKINE RECEPTORS | - |
dc.subject.keywordPlus | HEPATIC STEATOSIS | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordAuthor | HOMA-IR | - |
dc.subject.keywordAuthor | LPO | - |
dc.subject.keywordAuthor | MCP-1 | - |
dc.subject.keywordAuthor | renal lipid metabolism | - |
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