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JIP1 binding to RBP-Jk mediates cross-talk between the Notch1 and JIP1-JNK signaling pathway

Authors
Kim, M-YAnn, E-JMo, J-SDajas-Bailador, F.Seo, M-SHong, J-AJung, J.Choi, Y-HYoon, J-HKim, S-MChoi, E-JHoe, H-SWhitmarsh, A. J.Park, H-S
Issue Date
11월-2010
Publisher
NATURE PUBLISHING GROUP
Keywords
RBP-Jk; Notch1; JIP1; SH3 domain; cytoplasmic retention
Citation
CELL DEATH AND DIFFERENTIATION, v.17, no.11, pp.1728 - 1738
Indexed
SCIE
SCOPUS
Journal Title
CELL DEATH AND DIFFERENTIATION
Volume
17
Number
11
Start Page
1728
End Page
1738
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/115411
DOI
10.1038/cdd.2010.50
ISSN
1350-9047
Abstract
Notch1 signaling has a critical function in maintaining a balance among cell proliferation, differentiation, and apoptosis. Our earlier work showed that the Notch1 intracellular domain interferes with the scaffolding function of c-Jun N-terminal kinase (JNK)-interacting protein-1 (JIP1), yet the effect of JIP1 for Notch1-recombining binding protein suppressor of hairless (RBP-Jk) signaling remains unknown. Here, we show that JIP1 suppresses Notch1 activity. JIP1 was found to physically associate with either intracellular domain of Notch1 or RBP-Jk and interfere with the interaction between them. Furthermore, we ascertained that JIP1 caused the cytoplasmic retention of RBP-Jk through an interaction between the C-terminal region of JIP1 including Src homology 3 domain and the proline-rich domain of RBP-Jk. We also found that RBP-Jk inhibits JIP1-mediated activation of the JNK1 signaling cascade and cell death. Our results suggest that direct protein-protein interactions coordinate cross-talk between the Notch1-RBP-Jk and JIP1-JNK pathways. Cell Death and Differentiation (2010) 17, 1728-1738; doi:10.1038/cdd.2010.50; published online 28 May 2010
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