Association of a TGF-beta 1 gene -509 C/T polymorphism with breast cancer risk: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Woo, Sang Uk | - |
dc.contributor.author | Park, Kyong Hwa | - |
dc.contributor.author | Woo, Ok Hee | - |
dc.contributor.author | Yang, Dae Sik | - |
dc.contributor.author | Kim, Ae-Ree | - |
dc.contributor.author | Lee, Eun Sook | - |
dc.contributor.author | Lee, Jae-Bok | - |
dc.contributor.author | Kim, Yeul Hong | - |
dc.contributor.author | Kim, Jun Suk | - |
dc.contributor.author | Seo, Jae Hong | - |
dc.date.accessioned | 2021-09-07T23:15:59Z | - |
dc.date.available | 2021-09-07T23:15:59Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-11 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115432 | - |
dc.description.abstract | Transforming growth factor-beta 1 (TGF-beta 1) is negative regulator of cell proliferation and the cell cycle, and plasma levels of TGF-beta 1 are twice as high in TGF-beta 1 -509 T homozygotes as in -509 C homozygotes. Published studies on the association between the TGF-beta 1 gene -509 C/T polymorphism and breast cancer risk are inconclusive, and a meta-analysis is required to verify the association. We performed a meta-analysis of four studies, including a total of 5,986 cases and 6,829 controls. Our pooled results indicate that the TGF-beta 1 gene -509 C/T polymorphism is not associated with breast cancer risk in a TT versus CC codominant (OR = 1.08; 95% CI = 0.87-1.34; P = 0.494), in a CT versus CC codominant (OR = 1.02; 95% CI = 0.94-1.10; P = 0.686), recessive (OR = 0.92; 95% CI = 0.83-1.03; P = 0.157), and dominant (OR = 1.03; 95% CI = 0.96-1.11; P = 0.439) models. Conclusively, this meta-analysis suggests that the TGF-beta 1 gene -509 T allele polymorphism does not decrease breast cancer risk. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | TGF-BETA SUPERFAMILY | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | HUMAN-DISEASE | - |
dc.subject | TRANSFORMING-GROWTH-FACTOR-BETA-1 | - |
dc.subject | MECHANISMS | - |
dc.subject | RAS | - |
dc.title | Association of a TGF-beta 1 gene -509 C/T polymorphism with breast cancer risk: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Woo, Sang Uk | - |
dc.contributor.affiliatedAuthor | Park, Kyong Hwa | - |
dc.contributor.affiliatedAuthor | Yang, Dae Sik | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Bok | - |
dc.contributor.affiliatedAuthor | Seo, Jae Hong | - |
dc.identifier.doi | 10.1007/s10549-010-0871-6 | - |
dc.identifier.scopusid | 2-s2.0-78649333895 | - |
dc.identifier.wosid | 000283132800021 | - |
dc.identifier.bibliographicCitation | BREAST CANCER RESEARCH AND TREATMENT, v.124, no.2, pp.481 - 485 | - |
dc.relation.isPartOf | BREAST CANCER RESEARCH AND TREATMENT | - |
dc.citation.title | BREAST CANCER RESEARCH AND TREATMENT | - |
dc.citation.volume | 124 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 481 | - |
dc.citation.endPage | 485 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | TGF-BETA SUPERFAMILY | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | HUMAN-DISEASE | - |
dc.subject.keywordPlus | TRANSFORMING-GROWTH-FACTOR-BETA-1 | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | RAS | - |
dc.subject.keywordAuthor | TGF-beta 1 | - |
dc.subject.keywordAuthor | -509 C/T polymorphism | - |
dc.subject.keywordAuthor | Breast cancer risk | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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