Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice
- Authors
- Ahn, Eun Hee; Kim, Dae Won; Kang, Hye Won; Shin, Min Jae; Won, Moo Ho; Kim, Joon; Kim, Dong Joon; Kwon, Oh-Shin; Kang, Tae-Cheon; Han, Kyu Hyung; Park, Jinseu; Eum, Won Sik; Choi, Soo Young
- Issue Date
- 29-10월-2010
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Inflammation; MAPK; PEP-1-rpS3; TPA
- Citation
- TOXICOLOGY, v.276, no.3, pp.192 - 197
- Indexed
- SCIE
SCOPUS
- Journal Title
- TOXICOLOGY
- Volume
- 276
- Number
- 3
- Start Page
- 192
- End Page
- 197
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115489
- DOI
- 10.1016/j.tox.2010.08.004
- ISSN
- 0300-483X
- Abstract
- This study investigated the preventive effect of ribosomal protein S3 (rpS3) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice. A cell permeable expression vector PEP-1-rpS3 was constructed. Topical application of the vector markedly inhibited TPA-induced expression levels of cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines. Application of PEP-1-rpS3 also resulted in a significant reduction in the activation of nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinase (MAPK) in TPA-treated ears. These results indicate that PEP-1-rpS3 inhibits inflammatory response cytokines and enzymes by blocking NF-kappa B and MAPK, prompting the suggestion that PEP-1-rpS3 can be used as a therapeutic agent against skin inflammation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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