Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Young-Un | - |
dc.contributor.author | Jeong, Jaehoon | - |
dc.contributor.author | Lee, Haeryun | - |
dc.contributor.author | Mun, Ji Young | - |
dc.contributor.author | Kim, Joung-Hun | - |
dc.contributor.author | Lee, Jong Seo | - |
dc.contributor.author | Nguyen, Minh Dang | - |
dc.contributor.author | Han, Sung Sik | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Park, Sang Ki | - |
dc.date.accessioned | 2021-09-07T23:33:53Z | - |
dc.date.available | 2021-09-07T23:33:53Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-10-12 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115517 | - |
dc.description.abstract | Disrupted-in-schizophrenia 1 (DISC1) has emerged as a schizophrenia-susceptibility gene affecting various neuronal functions. In this study, we characterized Mitofilin, a mitochondrial inner membrane protein, as a mediator of the mitochondrial function of DISC1. A fraction of DISC1 was localized to the inside of mitochondria and directly interacts with Mitofilin. A reduction in DISC1 function induced mitochondrial dysfunction, evidenced by decreased mitochondrial NADH dehydrogenase activities, reduced cellular ATP contents, and perturbed mitochondrial Ca2+ dynamics. In addition, deficiencies in DISC1 and Mitofilin induced a reduction in mitochondrial monoamine oxidase-A activity. The mitochondrial dysfunctions evoked by the deficiency of DISC1 were partially pheno-copied by an overexpression of truncated DISC1 that is associated with schizophrenia in human. DISC1 deficiencies induced the ubiquitination of Mitofilin, suggesting that DISC1 is critical for the stability of Mitofilin. Finally, the mitochondrial dysfunction induced by DISC1 deficiency was partially reversed by coexpression of Mitofilin, confirming a functional link between DISC1 and Mitofilin for the normal mitochondrial function. According to these results, we propose that DISC1 plays essential roles for mitochondrial function in collaboration with a mitochondrial interacting partner, Mitofilin. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | COILED-COIL | - |
dc.subject | PROTEIN | - |
dc.subject | BINDING | - |
dc.subject | GENES | - |
dc.subject | BRAIN | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | PROLIFERATION | - |
dc.subject | METABOLISM | - |
dc.subject | MATRIX | - |
dc.subject | NUDEL | - |
dc.title | Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Sung Sik | - |
dc.identifier.doi | 10.1073/pnas.1004361107 | - |
dc.identifier.scopusid | 2-s2.0-78049249511 | - |
dc.identifier.wosid | 000282809700062 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.107, no.41, pp.17785 - 17790 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 107 | - |
dc.citation.number | 41 | - |
dc.citation.startPage | 17785 | - |
dc.citation.endPage | 17790 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | COILED-COIL | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | MATRIX | - |
dc.subject.keywordPlus | NUDEL | - |
dc.subject.keywordAuthor | IMMT | - |
dc.subject.keywordAuthor | mitochondrial dysfunctions | - |
dc.subject.keywordAuthor | hyperdopaminergia | - |
dc.subject.keywordAuthor | calcium buffering | - |
dc.subject.keywordAuthor | psychiatric disorders | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.