Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Grossman, Aaron W. | - |
dc.contributor.author | Aldridge, Georgina M. | - |
dc.contributor.author | Lee, Kea Joo | - |
dc.contributor.author | Zeman, Michelle K. | - |
dc.contributor.author | Jun, Christine S. | - |
dc.contributor.author | Azam, Humza S. | - |
dc.contributor.author | Arii, Tatsuo | - |
dc.contributor.author | Imoto, Keiji | - |
dc.contributor.author | Greenough, William T. | - |
dc.contributor.author | Rhyu, Im Joo | - |
dc.date.accessioned | 2021-09-07T23:36:11Z | - |
dc.date.available | 2021-09-07T23:36:11Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-10-08 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115524 | - |
dc.description.abstract | Fragile X Syndrome (FXS) is the most common form of inherited mental retardation. The neuroanatomical phenotype of adult FXS patients, as well as adult Fmr1 knockout (KO) mice, includes elevated dendritic spine density and a spine morphology profile in neocortex that resembles younger individuals. Developmental studies in mouse neocortex have revealed a dynamic phenotype that varies with age, especially during the period of synaptic pruning. Here we investigated the hippocampal dentate gyrus to determine if the FXS spine phenotype is similarly tied to periods of maturation and pruning in this brain region. We used high-voltage electron microscopy to characterize Golgi-stained spines along granule cell dendrites in Fmr1 KO and wildtype (WT) mouse dentate gyrus at postnatal days 15, 21, 30, and 60. In contrast to neocortex, dendritic spine density was higher in Fmr1 KO mice across development. Interestingly, neither genotype showed specific phases of synaptogenesis or pruning, potentially explaining the phenotypic differences from neocortex. Similarly, although the KO mice showed a more immature morphological phenotype overall than WT (higher proportion of thin headed spines, lower proportion of mushroom and stubby spines), both genotypes showed gradual development, rather than impairments during specific phases of maturation. Finally, spine length showed a complex developmental pattern that differs from other brain regions examined, suggesting dynamic regulation by FMRP and other brain region-specific proteins. These findings shed new light on FMRP's role in development and highlight the need for new techniques to further understand the mechanisms by which FMRP affects synaptic maturation. (C) 2010 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | FRAGILE-X-SYNDROME | - |
dc.subject | MENTAL-RETARDATION PROTEIN | - |
dc.subject | GRANULE CELL DENDRITES | - |
dc.subject | SOMATOSENSORY CORTEX | - |
dc.subject | PYRAMIDAL NEURONS | - |
dc.subject | VISUAL-CORTEX | - |
dc.subject | MOUSE MODEL | - |
dc.subject | RAT | - |
dc.subject | HIPPOCAMPUS | - |
dc.subject | MATURATION | - |
dc.title | Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rhyu, Im Joo | - |
dc.identifier.doi | 10.1016/j.brainres.2010.07.090 | - |
dc.identifier.scopusid | 2-s2.0-77956619092 | - |
dc.identifier.wosid | 000282504300023 | - |
dc.identifier.bibliographicCitation | BRAIN RESEARCH, v.1355, pp.221 - 227 | - |
dc.relation.isPartOf | BRAIN RESEARCH | - |
dc.citation.title | BRAIN RESEARCH | - |
dc.citation.volume | 1355 | - |
dc.citation.startPage | 221 | - |
dc.citation.endPage | 227 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | FRAGILE-X-SYNDROME | - |
dc.subject.keywordPlus | MENTAL-RETARDATION PROTEIN | - |
dc.subject.keywordPlus | GRANULE CELL DENDRITES | - |
dc.subject.keywordPlus | SOMATOSENSORY CORTEX | - |
dc.subject.keywordPlus | PYRAMIDAL NEURONS | - |
dc.subject.keywordPlus | VISUAL-CORTEX | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordAuthor | Plasticity | - |
dc.subject.keywordAuthor | Hippocampus | - |
dc.subject.keywordAuthor | Spine shape | - |
dc.subject.keywordAuthor | Activity dependent | - |
dc.subject.keywordAuthor | Development | - |
dc.subject.keywordAuthor | High-voltage electron microscopy | - |
dc.subject.keywordAuthor | Stereoscopic image | - |
dc.subject.keywordAuthor | Golgi impregnation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.