Functional monocyte chemoattractant protein-1 promoter-2518 polymorphism and systemic lupus erythematosus: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Woo, Jin-Hyun | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-07T23:43:32Z | - |
dc.date.available | 2021-09-07T23:43:32Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-10 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115566 | - |
dc.description.abstract | The monocyte chemoattractant protein-1 (MCP-1) promoter -2518 A/G polymorphism has been reported inconsistently to be associated with systemic lupus erythematosus (SLE) and lupus nephritis (LN). The aim of this study was to explore whether the MCP-1 polymorphism confers susceptibility to SLE or LN. We surveyed studies on the MCP-1 polymorphism and SLE or LN identified by MEDLINE or manual searches. Meta-analysis was conducted on the AA genotype (recessive effect), AA, and AG genotypes (dominant effect), AA versus GG (genotype contrast), and on the A allele of MCP-1 in SLE and LN in each ethnic population studied and on all subjects. Ten studies, which included 1,739 SLE patients and 1,680 controls, were included in our meta-analysis. These consisted of two European, six Asian, one Latin American, and one mixed study. We did not find any association between the MCP-1 -2518 A/G polymorphism and SLE in all subjects or in ethnic groups. Meta-analysis also failed to reveal an association between the MCP-1 -2518 A/G polymorphisms and LN. This meta-analysis on 3419 subjects indicates that no association exists between the MCP-1 -2518 A/G polymorphism and SLE or LN. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | REGULATORY REGION | - |
dc.subject | MCP-1 | - |
dc.subject | GENE | - |
dc.subject | ASSOCIATION | - |
dc.subject | NEPHRITIS | - |
dc.subject | ARTHRITIS | - |
dc.subject | GLOMERULONEPHRITIS | - |
dc.subject | EXPRESSION | - |
dc.subject | CHINESE | - |
dc.subject | DISEASE | - |
dc.title | Functional monocyte chemoattractant protein-1 promoter-2518 polymorphism and systemic lupus erythematosus: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s11033-009-9932-5 | - |
dc.identifier.scopusid | 2-s2.0-77956968766 | - |
dc.identifier.wosid | 000281985400050 | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.37, no.7, pp.3421 - 3426 | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 37 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 3421 | - |
dc.citation.endPage | 3426 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | REGULATORY REGION | - |
dc.subject.keywordPlus | MCP-1 | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | NEPHRITIS | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordPlus | GLOMERULONEPHRITIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CHINESE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | MCP-1 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Systemic lupus erythematosus | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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