Leukocyte Common Antigen-Related (LAR) Tyrosine Phosphatase Positively Regulates Osteoblast Differentiation by Modulating Extracellular Signal-Regulated Kinase (ERK) Activation
DC Field | Value | Language |
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dc.contributor.author | Kim, Won Kon | - |
dc.contributor.author | Bae, Kwang-Hee | - |
dc.contributor.author | Choi, Hye-Ryung | - |
dc.contributor.author | Kim, Do-Hyung | - |
dc.contributor.author | Choi, Kwang-Soo | - |
dc.contributor.author | Cho, Yee Sook | - |
dc.contributor.author | Kim, Hee Dai | - |
dc.contributor.author | Park, Sung Goo | - |
dc.contributor.author | Park, Byoung Chul | - |
dc.contributor.author | Ko, Yong | - |
dc.contributor.author | Lee, Sang Chul | - |
dc.date.accessioned | 2021-09-07T23:51:42Z | - |
dc.date.available | 2021-09-07T23:51:42Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-10 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115584 | - |
dc.description.abstract | Protein tyrosine phosphatases (PTPs) are pivotal regulators of key cellular functions, including cell growth, differentiation, and adhesion. Previously, we reported that leukocyte common antigen-related (LAR) tyrosine phosphatase promotes osteoblast differentiation in MC3T3-E1 preosteoblast cells. In the present study, the mechanism of the regulatory action of LAR on osteoblast differentiation was investigated. The mineralization of extracellular matrix and calcium accumulation in MC3T3-E1 cells were markedly enhanced by LAR overexpression, and these effects were further increased by treatment with an MEK inhibitor. In addition, LAR overexpression dramatically reduced extracellular signal-regulated kinase (Erk) activation during osteoblast differentiation. In contrast, a marginal effect of the inactive LAR mutant on Erk activation was detected. Expression of osteoblast-related genes such as ALP, BSP, DLX5, OCN, and RUNX2, was increased by LAR overexpression during osteoblast differentiation. On the basis of these results, we propose that LAR functions as a positive regulator of osteoblast differentiation by modulating ERK activation. Therefore, LAR phosphatase could be used as a novel regulatory target protein in many bone-associated diseases, including osteoporosis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.subject | BONE MORPHOGENETIC PROTEINS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | GROWTH-FACTORS | - |
dc.subject | MATRIX MINERALIZATION | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | PATHWAYS | - |
dc.subject | CELLS | - |
dc.subject | TRANSDUCTION | - |
dc.subject | PTP | - |
dc.title | Leukocyte Common Antigen-Related (LAR) Tyrosine Phosphatase Positively Regulates Osteoblast Differentiation by Modulating Extracellular Signal-Regulated Kinase (ERK) Activation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Yong | - |
dc.identifier.doi | 10.1007/s10059-010-0123-y | - |
dc.identifier.scopusid | 2-s2.0-78650511385 | - |
dc.identifier.wosid | 000284700000007 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.30, no.4, pp.335 - 340 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 30 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 335 | - |
dc.citation.endPage | 340 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001493941 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | BONE MORPHOGENETIC PROTEINS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | GROWTH-FACTORS | - |
dc.subject.keywordPlus | MATRIX MINERALIZATION | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
dc.subject.keywordPlus | PTP | - |
dc.subject.keywordAuthor | differentiation | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | LAR tyrosine phosphatase | - |
dc.subject.keywordAuthor | osteoblast | - |
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