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The Expression Profile and Function of Satb2 in Zebrafish Embryonic Development

Authors
Ahn, Hyun-JongPark, YoojinKim, SuhyunPark, Hae-chulSeo, Su-KyoungYeo, Sang-YeobGeum, Dongho
Issue Date
10월-2010
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Keywords
epiboly; Satb2; yolk syncytial layer; zebrafish
Citation
MOLECULES AND CELLS, v.30, no.4, pp.377 - 382
Indexed
SCIE
SCOPUS
KCI
Journal Title
MOLECULES AND CELLS
Volume
30
Number
4
Start Page
377
End Page
382
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/115625
DOI
10.1007/s10059-010-0128-6
ISSN
1016-8478
Abstract
The present study shows the expression profile and function of the homeobox gene, satb2 during zebrafish embryonic development. Satb2 was ubiquitously expressed from the 1 cell stage to the 10-somite stage in zebrafish embryos. Satb2 showed stage-specific expression profiles such as in the pronephric duct at 24 hpf, the branchial arches at 36 hpf, and the ganglion cell layer of the retina and fins at 48 hpf. Additionally, satb2 knockdown embryos were arrested at 50-60% epiboly, and transplantation experiments with satb2 knockdown cells showed migration defects. Interestingly, satb2 knockdown cells also exhibited down-regulation of dynamin II and VAMP4, which are involved in exocytosis and endocytosis, respectively. Furthermore, satb2 knockdown cells have a disorganized actin distribution and an underdeveloped external yolk syncytial layer, both of which are involved in epiboly. These results suggest that satb2 has a functional role in epiboly. This role may potentially be the regulation of endo-exocytic vesicle transport-dependent cell migration and/or the regulation of the development of the yolk syncytial layer.
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