Multiple mucosa-associated lymphoid tissue organs involving marginal zone B cell lymphoma: organ-specific relationships and the prognostic factors. Consortium for improving survival of lymphoma study
DC Field | Value | Language |
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dc.contributor.author | Oh, Sung Yong | - |
dc.contributor.author | Kim, Won Seog | - |
dc.contributor.author | Kim, Jin Seok | - |
dc.contributor.author | Kim, Seok Jin | - |
dc.contributor.author | Lee, Suee | - |
dc.contributor.author | Lee, Dae Ho | - |
dc.contributor.author | Won, Jong-Ho | - |
dc.contributor.author | Hwang, In Gyu | - |
dc.contributor.author | Kim, Min Kyoung | - |
dc.contributor.author | Il Lee, Soon | - |
dc.contributor.author | Chae, Yee Soo | - |
dc.contributor.author | Yang, Deok-Hwan | - |
dc.contributor.author | Kang, Hye Jin | - |
dc.contributor.author | Choi, Chul Won | - |
dc.contributor.author | Park, Jinny | - |
dc.contributor.author | Kim, Hyo Jung | - |
dc.contributor.author | Kwon, Jung Hye | - |
dc.contributor.author | Lee, Ho Sup | - |
dc.contributor.author | Lee, Gyeong-Won | - |
dc.contributor.author | Eom, Hyeon Seok | - |
dc.contributor.author | Kwak, Jae-Yong | - |
dc.contributor.author | Lee, Won Sik | - |
dc.contributor.author | Suh, Cheolwon | - |
dc.contributor.author | Kim, Hyo-Jin | - |
dc.date.accessioned | 2021-09-08T00:01:57Z | - |
dc.date.available | 2021-09-08T00:01:57Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-10 | - |
dc.identifier.issn | 0925-5710 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115637 | - |
dc.description.abstract | According to a previous review, multiple mucosa-associated lymphoid tissue (MALT)-organs involving marginal zone B cell lymphomas (MZLs) are present in 10-30% of patients. However, the clinical features and specific relationships among involved organs are yet to be clearly identified. In this study, we conducted retrospective analyses of multiple MALT organs involving MZLs (MM-MZLs) to identify their clinical features, treatment, prognosis, and specific relationships among involved organs. For analysis, between June 1987 and June 2009, a total of 55 patients from 17 different institutions in Korea, all of whom were histologically diagnosed with MM-MZL, were included in this study. MM-MZL was defined as MZL involving more than 2 different MALT organs. Multiple involvements within one MALT organ (e.g. both side ocular lesions, multiple lung nodules, and multiple stomach lesions, etc.) were excluded from this study. The male/female ratio of the 55 patients was 41/14. The median age of our subjects was 59 years (range 30-82 years). MM-MZL without lymph node (LN) was detected only in 9 patients (36.2%). Bone marrow (BM) involvement was observed in 17 patients (30.9%). The most common site of involvement was the gastrointestinal (GI) tract (25 patients, 45.5%) followed by the lung (40%), Waldeyer's ring (WR) (27.3%), and ocular area (25.5%). Ocular MZLs were commonly accompanied with WR- or lung-MZLs. GI-MZLs were WR or GI-MZLs. Lung-MZLs were frequently observed with ocular and GI-MZLs. WR-MZLs were ocular or GI-MZLs. A total of 53 patients were treated, and 2 on watchful wait. As much as 48 patients received chemotherapy-based treatment. Among them, CR or PR was achieved in 38 patients (79.2%, 95% CI 67-91%). Median time to progression (TTP) was 2.3 years (95% CI 1.4-3.2 years). Cause-specific overall survival (OS) did not reach the median value. The 5-year OS rate was 84.9%. MM-MZLs tend to be an indolent disease, characterized by prolonged survival with frequent relapses. The majority of cases could be controlled effectively via chemotherapy-based treatment, and prolonged survival was achieved in those patients. The GI, lung, WR, and ocular area were commonly presented with other MALT site MZLs, and an organ-specific relationship appears to be relevant to MM-MZLs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER JAPAN KK | - |
dc.subject | SINGLE-CENTER EXPERIENCE | - |
dc.subject | DISEASE | - |
dc.subject | DISSEMINATION | - |
dc.subject | PATTERNS | - |
dc.title | Multiple mucosa-associated lymphoid tissue organs involving marginal zone B cell lymphoma: organ-specific relationships and the prognostic factors. Consortium for improving survival of lymphoma study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Chul Won | - |
dc.identifier.doi | 10.1007/s12185-010-0680-z | - |
dc.identifier.scopusid | 2-s2.0-78549251362 | - |
dc.identifier.wosid | 000282633900014 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF HEMATOLOGY, v.92, no.3, pp.510 - 517 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF HEMATOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF HEMATOLOGY | - |
dc.citation.volume | 92 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 510 | - |
dc.citation.endPage | 517 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.subject.keywordPlus | SINGLE-CENTER EXPERIENCE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | DISSEMINATION | - |
dc.subject.keywordPlus | PATTERNS | - |
dc.subject.keywordAuthor | Multiple | - |
dc.subject.keywordAuthor | Mucosa-associated lymphoid tissues | - |
dc.subject.keywordAuthor | Marginal zone | - |
dc.subject.keywordAuthor | B cell lymphoma | - |
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