Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice
DC Field | Value | Language |
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dc.contributor.author | Choi, Jae-Hoon | - |
dc.contributor.author | Jeon, Hyung Jun | - |
dc.contributor.author | Park, Jong-Gil | - |
dc.contributor.author | Sonn, Seong Keun | - |
dc.contributor.author | Lee, Mi-Ran | - |
dc.contributor.author | Lee, Mi-Ni | - |
dc.contributor.author | You, Hye Jin | - |
dc.contributor.author | Kim, Geun-Young | - |
dc.contributor.author | Kim, Jae-Hong | - |
dc.contributor.author | Lee, Mun Han | - |
dc.contributor.author | Kwon, Oh-Seung | - |
dc.contributor.author | Nam, Ki-Hoan | - |
dc.contributor.author | Kim, Hyoung-Chin | - |
dc.contributor.author | Jeong, Tae-Sook | - |
dc.contributor.author | Lee, Woo Song | - |
dc.contributor.author | Oh, Goo Taeg | - |
dc.date.accessioned | 2021-09-08T00:23:40Z | - |
dc.date.available | 2021-09-08T00:23:40Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115730 | - |
dc.description.abstract | Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX), which play pivotal roles in atherogenesis, have been reported to be involved in plaque stability. Licofelone, a dual COX and 5-LOX inhibitor, has been reported to possess anti-atherogenic effect in rabbit atherosclerosis model. We therefore investigated the anti-atherogenic effect of BHB-TZD [5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazolidin-2,4-dione], a dual COX and 5-LOX inhibitor, in low density lipoprotein receptor null (LDLR-/-) mice. Fifteen LDLR-/- mice were fed a western diet (control group), whereas 15 were fed a western diet plus 0.1% (w/w) BHB-TZD (BHB-TZD group). After 8 weeks, the BHB-TZD group had markedly lower serum levels of leukotriene B4 and prostaglandin E2 than the control group. Interestingly, BHB-TZD treatment also reduced plasma triglyceride level without significant changes in total cholesterol and HDL levels. Compared with control mice, BHB-TZD fed mice had 52% fewer fatty streak lesions in the aortic sinus, as well as fewer initial lesions in the aortic arch. Macrophage infiltration into the lesions was 40% lower, and collagen and smooth muscle cells were increased by 102% and 96%, respectively, in the BHB-TZD group compared with the control group. In addition, aortic expression of proatherogenic molecules including TNF-alpha, IL-1 beta, IL-6, MCP-1 and VCAM-1, was lower in the BHB-TZD group than the control group. BHB-TZD treatment also reduced MMP-2 and MMP-9 expressions in aorta. In conclusion, BHB-TZD effectively attenuated atherosclerosis in mouse model, suggesting its therapeutic potential for atherosclerosis. (C) 2010 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | DEFICIENT MICE | - |
dc.subject | ATHEROSCLEROSIS | - |
dc.subject | PLAQUE | - |
dc.subject | PROSTACYCLIN | - |
dc.subject | INFLAMMATION | - |
dc.subject | MECHANISMS | - |
dc.subject | EXPRESSION | - |
dc.subject | PATHWAY | - |
dc.subject | DISEASE | - |
dc.subject | WALL | - |
dc.title | Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jae-Hong | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2010.05.003 | - |
dc.identifier.scopusid | 2-s2.0-77956232311 | - |
dc.identifier.wosid | 000281459900023 | - |
dc.identifier.bibliographicCitation | ATHEROSCLEROSIS, v.212, no.1, pp.146 - 152 | - |
dc.relation.isPartOf | ATHEROSCLEROSIS | - |
dc.citation.title | ATHEROSCLEROSIS | - |
dc.citation.volume | 212 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 146 | - |
dc.citation.endPage | 152 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | DEFICIENT MICE | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | PLAQUE | - |
dc.subject.keywordPlus | PROSTACYCLIN | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | WALL | - |
dc.subject.keywordAuthor | BHB-TZD | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | Cyclooxygenase | - |
dc.subject.keywordAuthor | 5-Lipoxygenase | - |
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