Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials
DC Field | Value | Language |
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dc.contributor.author | Jung, Ki-Young | - |
dc.contributor.author | Cho, Jae-Wook | - |
dc.contributor.author | Joo, Eun Yeon | - |
dc.contributor.author | Kim, Sun Hwa | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.contributor.author | Chin, Juhee | - |
dc.contributor.author | Park, Kun-Woo | - |
dc.contributor.author | Hong, Seung Bong | - |
dc.date.accessioned | 2021-09-08T00:26:26Z | - |
dc.date.available | 2021-09-08T00:26:26Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 1388-2457 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115746 | - |
dc.description.abstract | Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy. Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA). Results: Neuropsychological tests (n = 18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n = 13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions. Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects. Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | ANTIEPILEPTIC DRUGS | - |
dc.subject | SOURCE LOCALIZATION | - |
dc.subject | EPILEPTIC CHILDREN | - |
dc.subject | LAMOTRIGINE | - |
dc.subject | TASK | - |
dc.subject | EEG | - |
dc.subject | ERP | - |
dc.subject | VALPROATE | - |
dc.subject | THERAPY | - |
dc.subject | P300 | - |
dc.title | Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Ki-Young | - |
dc.contributor.affiliatedAuthor | Park, Kun-Woo | - |
dc.identifier.doi | 10.1016/j.clinph.2010.03.013 | - |
dc.identifier.scopusid | 2-s2.0-77955253764 | - |
dc.identifier.wosid | 000280555400012 | - |
dc.identifier.bibliographicCitation | CLINICAL NEUROPHYSIOLOGY, v.121, no.9, pp.1494 - 1501 | - |
dc.relation.isPartOf | CLINICAL NEUROPHYSIOLOGY | - |
dc.citation.title | CLINICAL NEUROPHYSIOLOGY | - |
dc.citation.volume | 121 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1494 | - |
dc.citation.endPage | 1501 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ANTIEPILEPTIC DRUGS | - |
dc.subject.keywordPlus | SOURCE LOCALIZATION | - |
dc.subject.keywordPlus | EPILEPTIC CHILDREN | - |
dc.subject.keywordPlus | LAMOTRIGINE | - |
dc.subject.keywordPlus | TASK | - |
dc.subject.keywordPlus | EEG | - |
dc.subject.keywordPlus | ERP | - |
dc.subject.keywordPlus | VALPROATE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | P300 | - |
dc.subject.keywordAuthor | Topiramate | - |
dc.subject.keywordAuthor | Cognitive function | - |
dc.subject.keywordAuthor | Event-related potential (ERP) | - |
dc.subject.keywordAuthor | Standardised low-resolution | - |
dc.subject.keywordAuthor | electromagnetic tomography (sLORETA) | - |
dc.subject.keywordAuthor | Source localisation | - |
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