The Analgesic Effect of Remifentanil on Prevention of Withdrawal Response Associated with the Injection of Rocuronium in Children: No Evidence for a Peripheral Action
- Authors
- Yoon, J. R.; Jeon, Y.; Yoo, Y.; Shin, H. J.; Ahn, J. H.; Lim, C. H.
- Issue Date
- 9월-2010
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- ROCURONIUM; REMIFENTANIL; WITHDRAWAL RESPONSE; CHILDREN; PAIN
- Citation
- JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v.38, no.5, pp.1795 - 1800
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Volume
- 38
- Number
- 5
- Start Page
- 1795
- End Page
- 1800
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115777
- DOI
- 10.1177/147323001003800526
- ISSN
- 0300-0605
- Abstract
- Remifentanil pre-treatment has been reported to decrease the incidence of rocuronium injection-associated withdrawal movement. This study was designed to explore the site of action of remifentanil for reducing withdrawal response during rocuronium injection in children. Ninety-six paediatric patients were randomly assigned to three groups. After induction of anaesthesia with 5 mg/kg 2.5% thiopental sodium, 2 ml saline (placebo group) or 0.5 mu g/kg remifentanil (group R), was injected intravenously 1 min before 0.6 mg/kg rocuronium. In a third group (group R'), the venous retention of 0.5 mu g/kg remifentanil was maintained for 30 s followed by tourniquet release and injection of 0.6 mg/kg rocuronium. Withdrawal response was graded using a four-point scale. The incidence of withdrawal movement after rocuronium administration was 94%, 22% and 81% in the placebo, R, and R' groups, respectively. This study demonstrated that the pre-treatment effect of remifentanil for reducing rocuronium-associated withdrawal response occurs mainly through a central action.
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