Cholinergic transmission in the dorsal hippocampus modulates trace but not delay fear conditioning
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pang, Min-Hee | - |
dc.contributor.author | Kim, Nam-Soo | - |
dc.contributor.author | Kim, Il-Hwan | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Kim, Hyun-Taek | - |
dc.contributor.author | Choi, June-Seek | - |
dc.date.accessioned | 2021-09-08T00:32:32Z | - |
dc.date.available | 2021-09-08T00:32:32Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 1074-7427 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115778 | - |
dc.description.abstract | Although cholinergic mechanisms have been widely implicated in learning and memory processes, few studies have investigated the specific contribution of hippocampal cholinergic transmission during trace fear conditioning, a form of associative learning involving a temporal gap between two stimuli. Microinfusions of scopolamine, a muscarinic receptor antagonist, into the dorsal hippocampus (DH) produced dose-dependent impairment in the acquisition and expression of a conditioned response (CR) following trace fear conditioning with a tone conditioned stimulus (CS) and a footshock unconditioned stimulus (US) in rats. The same infusions, however, had no effect on delay conditioning, general activity, pain sensitivity or attentional modulation. Moreover, scopolamine infusions attenuated phosphorylation of extracellular signal-regulated kinase (ERIC) in the amygdala, indicating that cholinergic signals in the DH are important for trace fear conditioning. Taken together, the current study provides evidence that cholinergic neurotransmission in the DH is essential for the cellular processing of CS-US association in the amygdala when the two stimuli are temporally disconnected. (C) 2010 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | LONG-TERM POTENTIATION | - |
dc.subject | NMDA RECEPTORS | - |
dc.subject | MEMORY CONSOLIDATION | - |
dc.subject | SYNAPTIC PLASTICITY | - |
dc.subject | BASAL FOREBRAIN | - |
dc.subject | SCOPOLAMINE | - |
dc.subject | AMYGDALA | - |
dc.subject | ACETYLCHOLINE | - |
dc.subject | ACQUISITION | - |
dc.subject | ACTIVATION | - |
dc.title | Cholinergic transmission in the dorsal hippocampus modulates trace but not delay fear conditioning | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun-Taek | - |
dc.contributor.affiliatedAuthor | Choi, June-Seek | - |
dc.identifier.doi | 10.1016/j.nlm.2010.05.008 | - |
dc.identifier.scopusid | 2-s2.0-77955562543 | - |
dc.identifier.wosid | 000281348100011 | - |
dc.identifier.bibliographicCitation | NEUROBIOLOGY OF LEARNING AND MEMORY, v.94, no.2, pp.206 - 213 | - |
dc.relation.isPartOf | NEUROBIOLOGY OF LEARNING AND MEMORY | - |
dc.citation.title | NEUROBIOLOGY OF LEARNING AND MEMORY | - |
dc.citation.volume | 94 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 206 | - |
dc.citation.endPage | 213 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | ahci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Behavioral Sciences | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychology | - |
dc.relation.journalWebOfScienceCategory | Behavioral Sciences | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Psychology | - |
dc.relation.journalWebOfScienceCategory | Psychology, Multidisciplinary | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | NMDA RECEPTORS | - |
dc.subject.keywordPlus | MEMORY CONSOLIDATION | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | BASAL FOREBRAIN | - |
dc.subject.keywordPlus | SCOPOLAMINE | - |
dc.subject.keywordPlus | AMYGDALA | - |
dc.subject.keywordPlus | ACETYLCHOLINE | - |
dc.subject.keywordPlus | ACQUISITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Trace fear conditioning | - |
dc.subject.keywordAuthor | Hippocampus | - |
dc.subject.keywordAuthor | Cholinergic system | - |
dc.subject.keywordAuthor | Scopolamine | - |
dc.subject.keywordAuthor | ERK | - |
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