Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy
DC Field | Value | Language |
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dc.contributor.author | Ko, S-H | - |
dc.contributor.author | Kwon, H-S | - |
dc.contributor.author | Yu, J-M | - |
dc.contributor.author | Baik, S-H | - |
dc.contributor.author | Park, I-B | - |
dc.contributor.author | Lee, J-H | - |
dc.contributor.author | Ko, K-S | - |
dc.contributor.author | Noh, J-H | - |
dc.contributor.author | Kim, D-S | - |
dc.contributor.author | Kim, C-H | - |
dc.contributor.author | Mok, J-O | - |
dc.contributor.author | Park, T-S | - |
dc.contributor.author | Son, H-S | - |
dc.contributor.author | Cha, B-Y | - |
dc.date.accessioned | 2021-09-08T00:33:15Z | - |
dc.date.available | 2021-09-08T00:33:15Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 0742-3071 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115782 | - |
dc.description.abstract | Aims This study compared the efficacy and safety of tramadol/acetaminophen (T/A) and gabapentin in the management of painful diabetic neuropathy. Methods An open, randomized, comparative study was conducted. Subjects with painful symmetric neuropathy in the lower limbs and mean pain-intensity score >= 4 on a numeric rating scale were eligible. Subjects were randomized to receive either tramadol (37.5 mg)/acetaminophen (325 mg) or gabapentin (300 mg) for 6 weeks. After 2 weeks of the titration period (1200 mg/day for gabapentin and three tablets/day for T/A), the doses were maintained if the pain was relieved. The primary efficacy outcome was a reduction in pain intensity. Secondary measures evaluated a pain relief scale, a Brief Pain Inventory, a 36-item Short Form Health Survey, average pain intensity and sleep disturbance. Results One hundred and sixty-three subjects (T/A 79; gabapentin 84) were included. At the final visit, the mean doses were 1575 mg/day for gabapentin and 4.22 tablets/day for T/A. Both groups were similar in terms of baseline pain intensity (mean intensity: T/A 6.7 +/- 1.6; gabapentin 6.3 +/- 1.6, P = 0.168). At the final visit, the mean reductions in pain intensity were similar in both groups (T/A -3.1 +/- 2.0; gabapentin -2.7 +/- 2.1, P = 0.744). Both groups had similar improvements in every Short Form Health Survey category and Brief Pain Inventory subcategory, and in the mean pain relief scores. Conclusion This study suggests that the T/A combination treatment is as effective as gabapentin in the treatment of painful diabetic neuropathy in patients with Type 2 diabetes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | DOUBLE-BLIND | - |
dc.subject | CONTROLLED-TRIAL | - |
dc.subject | POSTHERPETIC NEURALGIA | - |
dc.subject | PERIPHERAL NEUROPATHY | - |
dc.subject | NATURAL-HISTORY | - |
dc.subject | RISK-FACTORS | - |
dc.subject | TRAMADOL | - |
dc.subject | PLACEBO | - |
dc.subject | COMPLICATIONS | - |
dc.subject | EPIDEMIOLOGY | - |
dc.title | Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Baik, S-H | - |
dc.identifier.doi | 10.1111/j.1464-5491.2010.03054.x | - |
dc.identifier.scopusid | 2-s2.0-77955901067 | - |
dc.identifier.wosid | 000281062900010 | - |
dc.identifier.bibliographicCitation | DIABETIC MEDICINE, v.27, no.9, pp.1033 - 1040 | - |
dc.relation.isPartOf | DIABETIC MEDICINE | - |
dc.citation.title | DIABETIC MEDICINE | - |
dc.citation.volume | 27 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1033 | - |
dc.citation.endPage | 1040 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | POSTHERPETIC NEURALGIA | - |
dc.subject.keywordPlus | PERIPHERAL NEUROPATHY | - |
dc.subject.keywordPlus | NATURAL-HISTORY | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | TRAMADOL | - |
dc.subject.keywordPlus | PLACEBO | - |
dc.subject.keywordPlus | COMPLICATIONS | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordAuthor | diabetic complication | - |
dc.subject.keywordAuthor | painful diabetic neuropathy | - |
dc.subject.keywordAuthor | Type 2 diabetes mellitus | - |
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