TNF-alpha- induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X-L
DC Field | Value | Language |
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dc.contributor.author | Kim, J. J. | - |
dc.contributor.author | Lee, S. B. | - |
dc.contributor.author | Park, J. K. | - |
dc.contributor.author | Yoo, Y. D. | - |
dc.date.accessioned | 2021-09-08T00:35:08Z | - |
dc.date.available | 2021-09-08T00:35:08Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115791 | - |
dc.description.abstract | Reactive oxygen species (ROS) produced by tumor necrosis factor-a (TNF-alpha) have an important function in cell death by activating c-Jun N-terminal kinase. However, the exact mechanism of mitochondrial ROS production, after TNF-alpha stimulation, is not clearly understood. In this study, we determined that ROS modulator 1 (Romo1) and B-cell lymphoma-extra large (Bcl-X-L) are directly associated with TNF-alpha-induced ROS production. In response to TNF-alpha, TNF complex II, which consists of receptor-interacting protein 1, TNF receptor-associated protein with death domain, TNF receptor-associated factor 2, Fas-associated death domain protein, and pro-caspase-8, binds to the C-terminus of Romo1 located in the mitochondria. Concurrently, Romo1 recruits Bcl-X-L to reduce the mitochondrial membrane potential, resulting in ROS production and apoptotic cell death. On the basis of these results, we suggest that Romo1 is a molecular bridge between TNF-alpha signaling and the mitochondria for ROS production that triggers TNF-alpha-mediated apoptosis, as well as a novel target in the development of anti-inflammatory agents that block the origin of ROS production. Cell Death and Differentiation (2010) 17, 1420-1434; doi:10.1038/cdd.2010.19; published online 5 March 2010 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | OXYGEN SPECIES PRODUCTION | - |
dc.subject | NECROTIC CELL-DEATH | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | RECEPTOR | - |
dc.subject | ACTIVATION | - |
dc.subject | INDUCTION | - |
dc.subject | PROTEIN | - |
dc.subject | PATHWAYS | - |
dc.title | TNF-alpha- induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X-L | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Y. D. | - |
dc.identifier.doi | 10.1038/cdd.2010.19 | - |
dc.identifier.scopusid | 2-s2.0-77955713258 | - |
dc.identifier.wosid | 000280957000005 | - |
dc.identifier.bibliographicCitation | CELL DEATH AND DIFFERENTIATION, v.17, no.9, pp.1420 - 1434 | - |
dc.relation.isPartOf | CELL DEATH AND DIFFERENTIATION | - |
dc.citation.title | CELL DEATH AND DIFFERENTIATION | - |
dc.citation.volume | 17 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1420 | - |
dc.citation.endPage | 1434 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | OXYGEN SPECIES PRODUCTION | - |
dc.subject.keywordPlus | NECROTIC CELL-DEATH | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordAuthor | TNF-alpha | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | mitochondria | - |
dc.subject.keywordAuthor | Romo1 | - |
dc.subject.keywordAuthor | Bcl-X-L | - |
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