Aldosterone Modulates Cell Proliferation and Apoptosis in the Neonatal Rat Heart
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sohn, Hyung Joo | - |
dc.contributor.author | Yoo, Kee Hwan | - |
dc.contributor.author | Jang, Gi Young | - |
dc.contributor.author | Lee, Jang Hoon | - |
dc.contributor.author | Choi, Byung Min | - |
dc.contributor.author | Lee, Jung Hwa | - |
dc.contributor.author | Bae, In Sun | - |
dc.contributor.author | Yim, Hyung Eun | - |
dc.contributor.author | Son, Chang Sung | - |
dc.contributor.author | Lee, Joo Won | - |
dc.date.accessioned | 2021-09-08T00:38:43Z | - |
dc.date.available | 2021-09-08T00:38:43Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115810 | - |
dc.description.abstract | In the present study, we investigated whether and how the mineralocorticoid receptor antagonist spironolactone affects cardiac growth and development through apoptosis and cell proliferation in the neonatal rat heart. Newborn rat pups were treated with spironolactone (200 mg/kg/d) for 7 days. The cell proliferation was studied by PCNA immunostaining. The treatment with spironolactone decreased proliferating myocytes by 32% (P<0.05), and reduced myocytes apoptosis by 29% (P<0.05). Immunoblot and immunohistochemistry for the expression of p38, p53, clusterin, TGF-beta 2, and extracellular signal-regulated kinase were performed. In the spironolactone group, p38, p53, clusterin, and TGF-beta 2 protein expression was significantly decreased (P<0.05). These results indicate that aldosterone inhibition in the developing rat heart induces cardiac growth impairment by decreasing proliferation and apoptosis of myocytes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | RENIN-ANGIOTENSIN SYSTEM | - |
dc.subject | MYOCYTE APOPTOSIS | - |
dc.subject | CARDIAC-HYPERTROPHY | - |
dc.subject | P53 FUNCTION | - |
dc.subject | MAP KINASES | - |
dc.subject | IN-VIVO | - |
dc.subject | INHIBITION | - |
dc.subject | ACTIVATION | - |
dc.subject | DYSFUNCTION | - |
dc.subject | CLUSTERIN | - |
dc.title | Aldosterone Modulates Cell Proliferation and Apoptosis in the Neonatal Rat Heart | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Gi Young | - |
dc.contributor.affiliatedAuthor | Choi, Byung Min | - |
dc.contributor.affiliatedAuthor | Lee, Jung Hwa | - |
dc.contributor.affiliatedAuthor | Yim, Hyung Eun | - |
dc.contributor.affiliatedAuthor | Son, Chang Sung | - |
dc.contributor.affiliatedAuthor | Lee, Joo Won | - |
dc.identifier.doi | 10.3346/jkms.2010.25.9.1296 | - |
dc.identifier.scopusid | 2-s2.0-77956503721 | - |
dc.identifier.wosid | 000281511800006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.25, no.9, pp.1296 - 1304 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 25 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1296 | - |
dc.citation.endPage | 1304 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001469790 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | RENIN-ANGIOTENSIN SYSTEM | - |
dc.subject.keywordPlus | MYOCYTE APOPTOSIS | - |
dc.subject.keywordPlus | CARDIAC-HYPERTROPHY | - |
dc.subject.keywordPlus | P53 FUNCTION | - |
dc.subject.keywordPlus | MAP KINASES | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | CLUSTERIN | - |
dc.subject.keywordAuthor | Aldosterone | - |
dc.subject.keywordAuthor | Muscle Cells | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Cell Proliferation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.