Depletion of kidney CD11c(+) F4/80(+) cells impairs the recovery process in ischaemia/reperfusion-induced acute kidney injury
DC Field | Value | Language |
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dc.contributor.author | Kim, Myung-Gyu | - |
dc.contributor.author | Boo, Chang Su | - |
dc.contributor.author | Ko, Yoon Sook | - |
dc.contributor.author | Lee, Hee Young | - |
dc.contributor.author | Cho, Won Yong | - |
dc.contributor.author | Kim, Hyoung Kyu | - |
dc.contributor.author | Jo, Sang-Kyung | - |
dc.date.accessioned | 2021-09-08T00:43:33Z | - |
dc.date.available | 2021-09-08T00:43:33Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115834 | - |
dc.description.abstract | Background. Recent studies provided evidence of the potential role of CD11c(+) F4/80(+) dendritic subset in mediating injury and repair. The purpose of this study was to examine the role of kidney CD1 le F4/80(+) dendritic subset in the recovery phase of ischaemia/reperfusion injury (IRI). Methods. Following ischaemia/reperfusion (I/R), liposome clodronate or phosphate buffered saline (PBS) was administered, and on day 7 biochemical and histologic kidney damage was assessed. Activation and depletion of CD11c(+) F4/80(+) dendritic subset were confirmed by flow cytometry. Isolation of kidney C D I I e cells on days I and 7 with in vitro culture for measuring cytokines was performed to define functional characteristics of these cells, and adoptive transfer of CD11c(+) cells was also done. Results. Following kidney IRI, the percentage of CD11c(+) F4/80(+) kidney dendritic cell subset that co-expresses maturation marker increased. Liposome clodronate injection after I/R resulted in preferential depletion of CD11c(+) F4/80(+) kidney dendritic subset, and depletion of these cells was associated with persistent kidney injury, more apoptosis, inflammation and impaired tubular cell proliferation. CD11c(+) F4/80(+) cell depletion was also associated with higher tissue levels of pro-inflammatory cytokines and lower level of IL-10, indicating the persistence of inflammatory milieu. Isolated kidney CD11c(+) cells on day 7 showed different phenotype with increased production of IL-10 compared with those on day 1. Adoptive transfer of CD11c(+) cells partially reversed impaired tissue recovery. Conclusion. Our results suggest that kidney CD11c(+) F4/80(+) dendritic subset might contribute to the recovery process by dynamic phenotypic change from pro-inflammatory to anti-inflammatory with modulation of immune response. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | ACUTE-RENAL-FAILURE | - |
dc.subject | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject | REGULATORY T-CELLS | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | IFN-GAMMA | - |
dc.subject | ISCHEMIA/REPERFUSION INJURY | - |
dc.subject | MACROPHAGES | - |
dc.subject | MECHANISMS | - |
dc.subject | INDUCTION | - |
dc.subject | TOLERANCE | - |
dc.title | Depletion of kidney CD11c(+) F4/80(+) cells impairs the recovery process in ischaemia/reperfusion-induced acute kidney injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Won Yong | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Kyu | - |
dc.contributor.affiliatedAuthor | Jo, Sang-Kyung | - |
dc.identifier.doi | 10.1093/ndt/gfq183 | - |
dc.identifier.scopusid | 2-s2.0-77956254268 | - |
dc.identifier.wosid | 000282541600017 | - |
dc.identifier.bibliographicCitation | NEPHROLOGY DIALYSIS TRANSPLANTATION, v.25, no.9, pp.2908 - 2921 | - |
dc.relation.isPartOf | NEPHROLOGY DIALYSIS TRANSPLANTATION | - |
dc.citation.title | NEPHROLOGY DIALYSIS TRANSPLANTATION | - |
dc.citation.volume | 25 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2908 | - |
dc.citation.endPage | 2921 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | ACUTE-RENAL-FAILURE | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION INJURY | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | ISCHEMIA/REPERFUSION INJURY | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordAuthor | acute kidney injury | - |
dc.subject.keywordAuthor | dendritic subset | - |
dc.subject.keywordAuthor | liposome clodronate | - |
dc.subject.keywordAuthor | recovery | - |
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