Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor
DC Field | Value | Language |
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dc.contributor.author | Jin, Xun | - |
dc.contributor.author | Beck, Samuel | - |
dc.contributor.author | Sohn, Young-Woo | - |
dc.contributor.author | Kim, Jun-Kyum | - |
dc.contributor.author | Kim, Sung-Hak | - |
dc.contributor.author | Yin, Jinlong | - |
dc.contributor.author | Pian, Xumin | - |
dc.contributor.author | Kim, Sung-Chan | - |
dc.contributor.author | Choi, Yun-Jaie | - |
dc.contributor.author | Kim, Hyunggee | - |
dc.date.accessioned | 2021-09-08T00:47:07Z | - |
dc.date.available | 2021-09-08T00:47:07Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-08-31 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115853 | - |
dc.description.abstract | Although human telomerase catalytic subunit (TERT) has several cellular functions including telomere homeostasis, genomic stability, cell proliferation, and tumorigenesis, the molecular mechanism underlying anti-apoptosis regulated by TERT remains to be elucidated. Here, we show that ectopic expression of TEAT in spontaneously immortalized human fetal fibroblast (HFFS) cells, which are a telomerase- and p53-positive, leads to increases of cell proliferation and transformation, as well as a resistance to DNA damage response and inactivation of p53 function. We found that TEAT and a mutant TEAT (no telomerase activity) induce expression of basic fibroblast growth factor (bFGF), and ectopic expression of bFGF also allows cells to be resistant to DNA-damaging response and to suppress activation of p53 function under DNA-damaging induction. Furthermore, loss of TEAT or bFGF markedly increases a p53 activity and DNA-damage sensitivity in HFFS, HeLa and U87MG cells. Therefore, our findings indicate that a novel TERT-bFGF axis accelerates the inactivation of p53 and consequent increase of resistance to DNA-damage response. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | STRESS-INDUCED APOPTOSIS | - |
dc.subject | HUMAN CANCER-CELLS | - |
dc.subject | CONFERS RESISTANCE | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | P53 | - |
dc.subject | INHIBITION | - |
dc.subject | ACTIVATION | - |
dc.subject | CARCINOMA | - |
dc.subject | PATHWAY | - |
dc.title | Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jin, Xun | - |
dc.contributor.affiliatedAuthor | Kim, Sung-Hak | - |
dc.contributor.affiliatedAuthor | Kim, Hyunggee | - |
dc.identifier.doi | 10.3858/emm.2010.42.8.058 | - |
dc.identifier.scopusid | 2-s2.0-77957361644 | - |
dc.identifier.wosid | 000281437700005 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.42, no.8, pp.574 - 582 | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 42 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 574 | - |
dc.citation.endPage | 582 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001480942 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | STRESS-INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | HUMAN CANCER-CELLS | - |
dc.subject.keywordPlus | CONFERS RESISTANCE | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | bFGF | - |
dc.subject.keywordAuthor | basic fibroblast growth factor | - |
dc.subject.keywordAuthor | EGFR | - |
dc.subject.keywordAuthor | epidermal growth factor receptor | - |
dc.subject.keywordAuthor | HFFS | - |
dc.subject.keywordAuthor | human fetal fibroblast | - |
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