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Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity

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dc.contributor.authorKam, Yoo Lim-
dc.contributor.authorRhee, Hee-Kyung-
dc.contributor.authorRhim, Hyewhon-
dc.contributor.authorBack, Seung Keun-
dc.contributor.authorNa, Heung Sik-
dc.contributor.authorChoo, Hea-Young Park-
dc.date.accessioned2021-09-08T00:59:34Z-
dc.date.available2021-09-08T00:59:34Z-
dc.date.created2021-06-11-
dc.date.issued2010-08-15-
dc.identifier.issn0968-0896-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/115885-
dc.description.abstractNovel diphenylpiperazine derivatives were synthesized and evaluated for their inhibitory activity against T-type calcium channel by whole-cell patch clamp recordings on HEK293 cells. Among the test compounds, 2 and 3d were effective in decreasing the response to formalin in both the first and second phases and demonstrated antiallodynic effects in a rat model of neuropathic pain. (C) 2010 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectCA2+ CHANNELS-
dc.subjectPAIN-
dc.subjectRAT-
dc.subjectMIBEFRADIL-
dc.subjectALLODYNIA-
dc.subjectBLOCKERS-
dc.subjectMODEL-
dc.titleSynthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity-
dc.typeArticle-
dc.contributor.affiliatedAuthorNa, Heung Sik-
dc.identifier.doi10.1016/j.bmc.2010.06.082-
dc.identifier.scopusid2-s2.0-77955471833-
dc.identifier.wosid000280664100017-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, v.18, no.16, pp.5938 - 5944-
dc.relation.isPartOfBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.volume18-
dc.citation.number16-
dc.citation.startPage5938-
dc.citation.endPage5944-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusCA2+ CHANNELS-
dc.subject.keywordPlusPAIN-
dc.subject.keywordPlusRAT-
dc.subject.keywordPlusMIBEFRADIL-
dc.subject.keywordPlusALLODYNIA-
dc.subject.keywordPlusBLOCKERS-
dc.subject.keywordPlusMODEL-
dc.subject.keywordAuthorT-type calcium channel blocker-
dc.subject.keywordAuthorDiphenylpiperazine-
dc.subject.keywordAuthorFormalin test-
dc.subject.keywordAuthorNeuropathic pain-
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