Preparation of Acetylated Chitosan Sponges (Chitin Sponges)
- Authors
- Ko, Jung A.; Kim, Bum Keun; Park, Hyun Jin
- Issue Date
- 5-8월-2010
- Publisher
- WILEY
- Keywords
- chitosan; chitin; degree of acetylation; sponge; wound healing
- Citation
- JOURNAL OF APPLIED POLYMER SCIENCE, v.117, no.3, pp.1618 - 1623
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF APPLIED POLYMER SCIENCE
- Volume
- 117
- Number
- 3
- Start Page
- 1618
- End Page
- 1623
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115895
- DOI
- 10.1002/app.32053
- ISSN
- 0021-8995
- Abstract
- Acetylated chitosan sponges (chitin sponges) were prepared according to acetylation time (25, 50, 75, and 100 h). As the acetylation time increased, the degree of acetylation increased, and a 75-h acetylation time produced the highest degree of acetylation (DA). The surface morphologies of samples were examined by scanning electron microscopy. Sponge samples were shown by a water uptake ability test to have higher water absorption abilities. An in vitro biodegradation test showed that sponges with a higher DA were more susceptible to lysozyme hydrolysis. Acetylated chitosan sponges were further shown by an in vitro fibroblast proliferation test to have a higher degree of cell viability on increasing the DA, with 75 h exhibiting the maximum effect. The results showed that the wound healing effect of chitosan sponges can be controlled by the DA. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 117: 1618-1623, 2010
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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