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CIIA Is a Novel Regulator of Detachment-Induced Cell Death

Authors
Kim, Kwang JeYu, Je-WookHwang, Hyun SubChoi, Eui-Ju
Issue Date
1-8월-2010
Publisher
AMER ASSOC CANCER RESEARCH
Citation
CANCER RESEARCH, v.70, no.15, pp.6352 - 6358
Indexed
SCIE
SCOPUS
Journal Title
CANCER RESEARCH
Volume
70
Number
15
Start Page
6352
End Page
6358
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/115906
DOI
10.1158/0008-5472.CAN-09-4394
ISSN
0008-5472
Abstract
Detachment-induced cell death, or anoikis, is a type of apoptosis that occurs when epithelial cells lose their attachment to the extracellular matrix. Anoikis serves as a physiologic barrier to metastasis. Deviation from the tightly regulated mechanism of detachment-induced cell death might result in progression to metastatic cancer. Here, we investigated the function of CIIA in the regulation of anoikis. CIIA protein was upregulated in colon cancer tissue samples. Knockdown of CIIA in metastatic colorectal carcinoma SW620 and KM12SM cells promoted detachment-induced cell death through the regulation of caspase activation. Knockdown of CIIA also inhibited anchorage-independent growth in soft agar and colony formation after suspension stress. These observations suggest that CIIA is a novel negative regulator of anoikis. Cancer Res; 70( 15); 6352-8. (C) 2010 AACR.
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