TRIM72 negatively regulates myogenesis via targeting insulin receptor substrate-1
DC Field | Value | Language |
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dc.contributor.author | Lee, C. S. | - |
dc.contributor.author | Yi, J-S | - |
dc.contributor.author | Jung, S-Y | - |
dc.contributor.author | Kim, B-W | - |
dc.contributor.author | Lee, N-R | - |
dc.contributor.author | Choo, H-J | - |
dc.contributor.author | Jang, S-Y | - |
dc.contributor.author | Han, J. | - |
dc.contributor.author | Chi, S-G | - |
dc.contributor.author | Park, M. | - |
dc.contributor.author | Lee, J-H | - |
dc.contributor.author | Ko, Y-G | - |
dc.date.accessioned | 2021-09-08T01:11:40Z | - |
dc.date.available | 2021-09-08T01:11:40Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-08 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115954 | - |
dc.description.abstract | Lipid rafts have been known to be platforms to initiate cellular signal transduction of insulin-like growth factor (IGF) inducing skeletal muscle differentiation and hypertrophy. Here, tripartite motif 72 (TRIM72), with a really interesting new gene (RING)finger domain, a B-box, two coiled-coil domains, and a SPRY (SPla and RYanodine receptor) domain, was revealed to be predominantly expressed in the sarcolemma lipid rafts of skeletal and cardiac muscles. Adenoviral TRIM72 overexpression prevented but RNAi-mediated TRIM72 silencing enhanced C2C12 myogenesis by modulating the IGF-induced insulin receptor substrate-1 (IRS-1) activation through the molecular association of TRIM72 with IRS-1. Furthermore, myogenic activity was highly enhanced with increased IGF-induced Akt activation in the satellite cells of TRIM72(-/-) mice, compared to those of TRIM72(+/+) mice. Because TRIM72 promoter analysis shows that two proximal E-boxes in TRIM72 promoter were essential for MyoD- and Akt-dependent TRIM72 transcription, we can conclude that TRIM72 is a novel antagonist of IRS-1, and is essential as a negative regulator of IGF-induced muscle differentiation. Cell Death and Differentiation (2010) 17, 1254-1265; doi:10.1038/cdd.2010.1; published online 5 February 2010 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | SKELETAL-MUSCLE HYPERTROPHY | - |
dc.subject | GIRDLE MUSCULAR-DYSTROPHY | - |
dc.subject | ATP SYNTHASE COMPLEX | - |
dc.subject | LIPID RAFTS REVEALS | - |
dc.subject | GROWTH-FACTOR-II | - |
dc.subject | UBIQUITIN LIGASE | - |
dc.subject | TRANSCRIPTION FACTORS | - |
dc.subject | MOLECULAR-MECHANISMS | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | CELL-SURFACE | - |
dc.title | TRIM72 negatively regulates myogenesis via targeting insulin receptor substrate-1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yi, J-S | - |
dc.contributor.affiliatedAuthor | Chi, S-G | - |
dc.contributor.affiliatedAuthor | Ko, Y-G | - |
dc.identifier.doi | 10.1038/cdd.2010.1 | - |
dc.identifier.scopusid | 2-s2.0-77954659591 | - |
dc.identifier.wosid | 000279725900006 | - |
dc.identifier.bibliographicCitation | CELL DEATH AND DIFFERENTIATION, v.17, no.8, pp.1254 - 1265 | - |
dc.relation.isPartOf | CELL DEATH AND DIFFERENTIATION | - |
dc.citation.title | CELL DEATH AND DIFFERENTIATION | - |
dc.citation.volume | 17 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1254 | - |
dc.citation.endPage | 1265 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE HYPERTROPHY | - |
dc.subject.keywordPlus | GIRDLE MUSCULAR-DYSTROPHY | - |
dc.subject.keywordPlus | ATP SYNTHASE COMPLEX | - |
dc.subject.keywordPlus | LIPID RAFTS REVEALS | - |
dc.subject.keywordPlus | GROWTH-FACTOR-II | - |
dc.subject.keywordPlus | UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | CELL-SURFACE | - |
dc.subject.keywordAuthor | TRIM72 | - |
dc.subject.keywordAuthor | lipid rafts | - |
dc.subject.keywordAuthor | myogenesis | - |
dc.subject.keywordAuthor | insulin receptor substrate-1 | - |
dc.subject.keywordAuthor | insulin-like growth factor | - |
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