Statins Do Not Decrease Small, Dense Low-Density Lipoprotein
- Authors
- Choi, Cheol Ung; Seo, Hong Seog; Lee, Eun Mi; Shin, Seung Yong; Choi, Un-Jung; Na, Jin Oh; Lim, Hong Euy; Kim, Jin Won; Kim, Eung Ju; Rha, Seung-Woon; Park, Chang Gyu; Oh, Dong Joo
- Issue Date
- 8월-2010
- Publisher
- TEXAS HEART INST
- Keywords
- Antilipemic agents/therapeutic use; arteriosclerosis/blood; biological markers/blood; cholesterol, LDL/analysis/blood/classification/drug effects; coronary artery disease/prevention & control/therapy; hyperlipidemias/prevention & control; lipids; lipoproteins, LDL/blood/chemistry; particle size
- Citation
- TEXAS HEART INSTITUTE JOURNAL, v.37, no.4, pp.421 - 428
- Indexed
- SCOPUS
- Journal Title
- TEXAS HEART INSTITUTE JOURNAL
- Volume
- 37
- Number
- 4
- Start Page
- 421
- End Page
- 428
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115993
- ISSN
- 1526-6702
- Abstract
- In an observational study, we examined the effect of statins on low-density-lipoprotein (LDL) sub fractions. Using density-gradient ultracentrifugation, we measured small, dense LDL density in 612 patients (mean age, 61.7 +/- 12.6 yr), some with and some without coronary artery disease, who were placed in a statin-treated group (n=172) or a control group (n=440) and subdivided on the basis of coronary artery disease status. Total cholesterol, LDL cholesterol, apolipoprotein 8, and the LDL cholesterol/apolipoprotein 8 ratio were significantly lower in the statin group. However, the proportion of small, dense LDL was higher in the statin group (42.9% +/- 9.5% vs 41.3% +/- 8.5%; P=0.046) and the proportion of large, buoyant LDL was lower (23.6% +/- 75% vs 25.4% +/- 7.9%; P=0.011). In the statin group, persons without coronary artery disease had higher proportions of small, dense LDL, and persons with coronary artery disease tended to have higher proportions of small, dense LDL. Our study suggests that statin therapy-whether or not recipients have coronary artery disease-does not decrease the proportion of small, dense LDL among total LDL particles, but in fact increases it, while predictably reducing total LDL cholesterol, absolute amounts of small, dense LDL, and absolute amounts of large, buoyant LDL. If and when our observation proves to be reproducible in subsequent large-scale studies, it should provide new insights into small, dense LDL and its actual role in atherogenesis or the progression of atherosclerosis. (Tex Heart Inst J 2010;37(4);421-8)
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- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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