G protein beta 3 subunit, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms in Koreans with irritable bowel syndrome
DC Field | Value | Language |
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dc.contributor.author | Lee, H. -J. | - |
dc.contributor.author | Lee, S. -Y. | - |
dc.contributor.author | Choi, J. E. | - |
dc.contributor.author | Kim, J. H. | - |
dc.contributor.author | Sung, I. -K. | - |
dc.contributor.author | Park, H. S. | - |
dc.contributor.author | Jin, C. J. | - |
dc.date.accessioned | 2021-09-08T01:47:36Z | - |
dc.date.available | 2021-09-08T01:47:36Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-07 | - |
dc.identifier.issn | 1350-1925 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116144 | - |
dc.description.abstract | Background The association between irritable bowel syndrome (IBS) based on Rome III criteria and G protein beta 3 subunit (GNB3), interleukin (IL)-10, and tumor necrosis factor (TNF)-alpha gene polymorphisms is uncertain. Methods Case and control subjects were recruited from Korean visitors to the Health Promotion Center and Digestive Disease Center for gastrointestinal endoscopy. G protein beta 3 subunit, IL-10, and TNF-alpha gene polymorphisms were genotyped using a polymerase chain reaction-based method. Multifactor dimensionality reduction (MDR) analysis was used to assess gene-gene interactions. Key Results Genotype and allele frequencies of GNB3 showed marginal significance between the healthy controls and IBS patients (chi 2 = 5.92, P = 0.052; chi 2 = 3.76, P = 0.053). G protein beta 3 subunit T allele was more strongly correlated with IBS with constipation (12 of constipation-dominant type and 31 of mixed type) than with 51 diarrhea-dominant type and 88 normal subjects (chi 2 = 13.91, P = 0.008). Multifactor dimensionality reduction analysis revealed that there were no significant interactions of GNB3, IL-10, and TNF-alpha gene variants with susceptibility to IBS (P > 0.05). Conclusions & Inferences The results suggest that GNB3 825T allele might be associated with IBS with constipation in Koreans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | ETHNIC DISTRIBUTION | - |
dc.subject | 825T ALLELE | - |
dc.subject | IDENTIFICATION | - |
dc.subject | ASSOCIATION | - |
dc.subject | REDUCTION | - |
dc.subject | DISEASE | - |
dc.subject | LOCI | - |
dc.title | G protein beta 3 subunit, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms in Koreans with irritable bowel syndrome | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, H. -J. | - |
dc.identifier.doi | 10.1111/j.1365-2982.2010.01496.x | - |
dc.identifier.scopusid | 2-s2.0-77953347058 | - |
dc.identifier.wosid | 000278525200007 | - |
dc.identifier.bibliographicCitation | NEUROGASTROENTEROLOGY AND MOTILITY, v.22, no.7, pp.758 - 763 | - |
dc.relation.isPartOf | NEUROGASTROENTEROLOGY AND MOTILITY | - |
dc.citation.title | NEUROGASTROENTEROLOGY AND MOTILITY | - |
dc.citation.volume | 22 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 758 | - |
dc.citation.endPage | 763 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ETHNIC DISTRIBUTION | - |
dc.subject.keywordPlus | 825T ALLELE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | REDUCTION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | LOCI | - |
dc.subject.keywordAuthor | G protein | - |
dc.subject.keywordAuthor | irritable bowel syndrome | - |
dc.subject.keywordAuthor | poly-morphism | - |
dc.subject.keywordAuthor | Rome III criteria | - |
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