Microglial peroxiredoxin V acts as an inducible anti-inflammatory antioxidant through cooperation with redox signaling cascades
DC Field | Value | Language |
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dc.contributor.author | Sun, Hu-Nan | - |
dc.contributor.author | Kim, Sun-Uk | - |
dc.contributor.author | Huang, Song Mei | - |
dc.contributor.author | Kim, Jin-Man | - |
dc.contributor.author | Park, Young-Ho | - |
dc.contributor.author | Kim, Seok-Ho | - |
dc.contributor.author | Yang, Hee-Young | - |
dc.contributor.author | Chung, Kyoung-Jin | - |
dc.contributor.author | Lee, Tae-Hoon | - |
dc.contributor.author | Choi, Hoon Sung | - |
dc.contributor.author | Min, Ju Sik | - |
dc.contributor.author | Park, Moon-Ki | - |
dc.contributor.author | Kim, Sang-Keun | - |
dc.contributor.author | Lee, Sang-Rae | - |
dc.contributor.author | Chang, Kyu-Tae | - |
dc.contributor.author | Lee, Sang-Ho | - |
dc.contributor.author | Yu, Dae-Yeul | - |
dc.contributor.author | Lee, Dong-Seok | - |
dc.date.accessioned | 2021-09-08T01:49:29Z | - |
dc.date.available | 2021-09-08T01:49:29Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-07 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116155 | - |
dc.description.abstract | P>Reactive oxygen species (ROS) actively participate in microglia-mediated pathogenesis as pro-inflammatory molecules. However, little is known about the involvement of specific antioxidants in maintaining the microglial oxidative balance. We demonstrate that microglial peroxiredoxin (Prx) 5 expression is up-regulated by lipopolysaccharide (LPS) through activation of the ROS-sensitive signaling pathway and is involved in attenuation of both microglial activation and nitric oxide (NO) generation. Unlike in stimulation of oxidative insults with paraquat and hydrogen peroxide, Prx V expression is highly sensitive to LPS-stimulation in microglia. Reduction of ROS level by treatment with either NADPH oxidase inhibitor or antioxidant ablates LPS-mediated Prx V up-regulation in BV-2 microglial cells and is closely associated with the activation of the c-jun N-terminal kinase (JNK) signaling pathway. This suggests the involvement of ROS/JNK signaling in LPS-mediated Prx V induction. Furthermore, NO induces Prx V up-regulation that is ablated by the addition of inducible nitric oxide synthase inhibitor or deleted mutation of inducible nitric oxide synthase in LPS-stimulated microglia. Therefore, these results suggest that Prx V is induced by cooperative action among the ROS, RNS, and JNK signaling cascades. Interestingly, knockdown of Prx V expression causes the acceleration of microglia activation, including augmented ROS generation and JNK-dependent NO production. In summary, we demonstrate that Prx V plays a key role in the microglial activation process through modulation of the balance between ROS/NO generation and the corresponding JNK cascade activation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | HYDROGEN-PEROXIDE | - |
dc.subject | PROSTAGLANDIN E-2 | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | TNF-ALPHA | - |
dc.subject | LIPOPOLYSACCHARIDE | - |
dc.subject | EXPRESSION | - |
dc.subject | ACTIVATION | - |
dc.subject | PROTECTS | - |
dc.title | Microglial peroxiredoxin V acts as an inducible anti-inflammatory antioxidant through cooperation with redox signaling cascades | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Ho | - |
dc.identifier.doi | 10.1111/j.1471-4159.2010.06691.x | - |
dc.identifier.scopusid | 2-s2.0-77953305948 | - |
dc.identifier.wosid | 000278567100004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROCHEMISTRY, v.114, no.1, pp.39 - 50 | - |
dc.relation.isPartOf | JOURNAL OF NEUROCHEMISTRY | - |
dc.citation.title | JOURNAL OF NEUROCHEMISTRY | - |
dc.citation.volume | 114 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 39 | - |
dc.citation.endPage | 50 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | PROSTAGLANDIN E-2 | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordAuthor | c-jun N-terminal kinase | - |
dc.subject.keywordAuthor | lipopolysaccharide | - |
dc.subject.keywordAuthor | microglia | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | peroxiredoxin V | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
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