An Electron Microscopic Study-Correlation of Gastroesophageal Reflux Disease and Laryngopharyngeal Reflux
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sanghoon | - |
dc.contributor.author | Chun, Hoon Jai | - |
dc.contributor.author | Keum, Bora | - |
dc.contributor.author | Uhm, Chang-Sub | - |
dc.contributor.author | Baek, Seung-Kuk | - |
dc.contributor.author | Jung, Kwang-Yoon | - |
dc.contributor.author | Lee, Sung Joon | - |
dc.date.accessioned | 2021-09-08T01:51:10Z | - |
dc.date.available | 2021-09-08T01:51:10Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-07 | - |
dc.identifier.issn | 0023-852X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116165 | - |
dc.description.abstract | Objectives/Hypothesis: Laryngopharyngeal reflux (LPR) originates from regurgitation of gastric contents, a mechanism seemingly identical to gastroesophageal reflux disease (GERD). Some researchers postulate a connection between LPR and GERD, whereas some assert LPR is a disease apart from GERD. We examined symptoms of GERD from LPR patients, and performed gastrointestinal endoscopy and transmission electron microscopy (TEM) to evaluate GERD findings from these patients. Study Design: Prospective study at an academic tertiary care center. Methods: Control subjects had no symptoms or signs of LPR/GERD. LPR was diagnosed with a Reflux Symptom Index >13 and Reflux Finding Score >7, and were questioned for GERD-related symptoms and examined with esophagogastroduodenoscopy, then allocated into either an LPR without GERD or LPR with GERD group. Esophageal tissues were obtained from the squamocolumnar junction and managed for TEM, and the intercellular space (IS) was measured to find dilatation, a characteristic GERD finding. Results: About 30% (8/26) of LPR patients showed GERD-related symptoms, connecting LPR with the GERD group. Most of the LPR patients showed grossly normal endoscopic findings. On TEM, IS of control group (n = 15) was measured as 0.35 +/- 0.27 mu m, whereas the LPR without GERD group (n = 18) and LPR with GERD group (n = 8) revealed a dilated IS of 0.61 +/- 0.47 mu m and 0.95 +/- 0.44 mu m, respectively. This difference was statistically significant compared to the control group (P < .05). Conclusions: The mean IS of LPR was significantly increased, suggesting common pathogenesis between LPR and GERD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | DILATED INTERCELLULAR SPACES | - |
dc.subject | ACID | - |
dc.subject | GERD | - |
dc.subject | RELIABILITY | - |
dc.subject | SYMPTOMS | - |
dc.subject | VALIDITY | - |
dc.subject | THERAPY | - |
dc.subject | RELIEF | - |
dc.title | An Electron Microscopic Study-Correlation of Gastroesophageal Reflux Disease and Laryngopharyngeal Reflux | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chun, Hoon Jai | - |
dc.contributor.affiliatedAuthor | Keum, Bora | - |
dc.contributor.affiliatedAuthor | Uhm, Chang-Sub | - |
dc.contributor.affiliatedAuthor | Baek, Seung-Kuk | - |
dc.contributor.affiliatedAuthor | Jung, Kwang-Yoon | - |
dc.identifier.doi | 10.1002/lary.20918 | - |
dc.identifier.scopusid | 2-s2.0-77954411858 | - |
dc.identifier.wosid | 000279498500005 | - |
dc.identifier.bibliographicCitation | LARYNGOSCOPE, v.120, no.7, pp.1303 - 1308 | - |
dc.relation.isPartOf | LARYNGOSCOPE | - |
dc.citation.title | LARYNGOSCOPE | - |
dc.citation.volume | 120 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1303 | - |
dc.citation.endPage | 1308 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.subject.keywordPlus | DILATED INTERCELLULAR SPACES | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | GERD | - |
dc.subject.keywordPlus | RELIABILITY | - |
dc.subject.keywordPlus | SYMPTOMS | - |
dc.subject.keywordPlus | VALIDITY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | RELIEF | - |
dc.subject.keywordAuthor | Gastroesophageal reflux disease | - |
dc.subject.keywordAuthor | laryngopharyngeal reflux | - |
dc.subject.keywordAuthor | transmission electron microscopy | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.