C-Methylflavonoids Isolated from Callistemon lanceolatus Protect PC12 Cells against A beta-Induced Toxicity
DC Field | Value | Language |
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dc.contributor.author | Park, So-Young | - |
dc.contributor.author | Lim, Ji-Youn | - |
dc.contributor.author | Jeong, Wonsik | - |
dc.contributor.author | Hong, Seong Su | - |
dc.contributor.author | Yang, Young Taek | - |
dc.contributor.author | Hwang, Bang Yeon | - |
dc.contributor.author | Lee, Dongho | - |
dc.date.accessioned | 2021-09-08T02:54:41Z | - |
dc.date.available | 2021-09-08T02:54:41Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-06 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116390 | - |
dc.description.abstract | Increased beta-amyloid (A beta) production and its aggregation to the oligomeric state is considered to be a major cause of Alzheimer's disease (AD). Therefore, reducing A beta-induced neurotoxicity could provide a suitable means of prevention or intervention in the disease course of AD. The neuroprotective effects of isolates from Callistemon lanceolatus DC. (Myrtaceae) against A beta were evaluated using PC12 cells. To evaluate the effects of A beta on apoptotic cell death and the effects of Bcl-2 family proteins and caspase-3, TUNEL assays and Western blotting were performed, respectively. Substantial fractionation and purification of the EtOAc-soluble extract of the aerial parts of C. lanceolatus afforded six flavonoids, 4',5-dihydroxy-6,8-dimethyl-7-methoxyflavanone (1), eucalyptin (2), 8-demethyleucalyptin (3), sideroxylin (4), syzalterin (5), and quercetin (6). Compounds 1, 5, and 6 were found to protect PC12 cells effectively against A beta-induced toxicity. In particular, compound 1 showed the most promising neuroprotective effect with an ED50 value of 6.7 mu M in terms of decreasing A beta-induced apoptotic cell death, and this was accompanied by a decrease in caspase-3 activation and an increase in Bcl-2/Bax ratio. These results suggest that compound 1 could be developed as a candidate anti-AD agent due to its attenuation of A beta-induced apoptotic cell death. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | GEORG THIEME VERLAG KG | - |
dc.subject | ALDOSE REDUCTASE INHIBITORS | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | METHYL-FLAVONOIDS | - |
dc.subject | EXPRESSION | - |
dc.subject | CONSTITUENTS | - |
dc.title | C-Methylflavonoids Isolated from Callistemon lanceolatus Protect PC12 Cells against A beta-Induced Toxicity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.1055/s-0029-1240801 | - |
dc.identifier.scopusid | 2-s2.0-77953819386 | - |
dc.identifier.wosid | 000279668400004 | - |
dc.identifier.bibliographicCitation | PLANTA MEDICA, v.76, no.9, pp.863 - 868 | - |
dc.relation.isPartOf | PLANTA MEDICA | - |
dc.citation.title | PLANTA MEDICA | - |
dc.citation.volume | 76 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 863 | - |
dc.citation.endPage | 868 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ALDOSE REDUCTASE INHIBITORS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | METHYL-FLAVONOIDS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordAuthor | Callistemon lanceolatus | - |
dc.subject.keywordAuthor | Myrtaceae | - |
dc.subject.keywordAuthor | beta-amyloid | - |
dc.subject.keywordAuthor | 4 &apos | - |
dc.subject.keywordAuthor | ,5dihydroxy-6,8-dimethyl-7-methoxyflavanone | - |
dc.subject.keywordAuthor | C-methylflavonoids | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | PC12 cells | - |
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