Serum n-6 fatty acids and lipoprotein subclasses in middle-aged men: the population-based cross-sectional ERA-JUMP Study
DC Field | Value | Language |
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dc.contributor.author | Choo, Jina | - |
dc.contributor.author | Ueshima, Hirotsugu | - |
dc.contributor.author | Curb, J. David | - |
dc.contributor.author | Shin, Chol | - |
dc.contributor.author | Evans, Rhobert W. | - |
dc.contributor.author | El-Saed, Aiman | - |
dc.contributor.author | Kadowaki, Takashi | - |
dc.contributor.author | Okamura, Tomonori | - |
dc.contributor.author | Nakata, Katsumi | - |
dc.contributor.author | Otake, Teruo | - |
dc.contributor.author | Miura, Katsuyuki | - |
dc.contributor.author | Abbott, Robert D. | - |
dc.contributor.author | Sutton-Tyrrell, Kim | - |
dc.contributor.author | Edmundowicz, Daniel | - |
dc.contributor.author | Kuller, Lewis H. | - |
dc.contributor.author | Sekikawa, Akira | - |
dc.date.accessioned | 2021-09-08T03:11:48Z | - |
dc.date.available | 2021-09-08T03:11:48Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-05-01 | - |
dc.identifier.issn | 0002-9165 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116470 | - |
dc.description.abstract | Background: The associations of serum omega-6 (n-6) fatty acids with lipoprotein subclasses at the population level are uncertain. Objective: We aimed to examine associations between major n-6 fatty acids [ie, linoleic acid (LA, 18:2n-6) and arachidonic acid (AA, 20:4n-6)] and the lipoprotein subclasses VLDL, LDL, and HDL. Design: We conducted a cross-sectional study in 1098 participants using population-based data from US white, Japanese American, Japanese, and Korean men aged 40-49 y. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Lipoprotein subclasses were measured by nuclear magnetic resonance spectroscopy. Multiple linear regression models as a function of each fatty acid were used after adjustment for age, population, body mass index, pack-years of smoking, alcohol consumption, diabetes, hypertension, and omega-3 (n-3) and trans fatty acids. Results: Serum LA was inversely associated with large VLDL (beta = -0.62, P < 0.001), total LDL (beta = -22.08, P < 0.001), and small LDL (beta = -31.89, P < 0.001) particle concentrations and VLDL size (beta = -0.72, P < 0.001). Serum LA was positively associated with large HDL particle concentration (beta = 0.21, P < 0.001) and HDL size (beta = 0.03, P < 0.001). The patterns of association of AA with large VLDL and large HDL particle concentrations were comparable with those of LA. Conclusions: At the population level, higher serum concentrations of LA were significantly associated with lower concentrations of total LDL particles. Higher serum concentrations of LA and AA were significantly associated with a lower concentration of large VLDL particles and a higher concentration of large HDL particles. These associations were consistent across the population groups. This trial was registered at clinicaltrials.gov as NCT00069797. Am J Clin Nutr 2010; 91: 1195-203. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | CORONARY-HEART-DISEASE | - |
dc.subject | MAGNETIC-RESONANCE-SPECTROSCOPY | - |
dc.subject | LOW-DENSITY-LIPOPROTEIN | - |
dc.subject | DIETARY LINOLEIC-ACID | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | PARTICLE SUBCLASSES | - |
dc.subject | POLYUNSATURATED FAT | - |
dc.subject | ARACHIDONIC-ACID | - |
dc.subject | UNITED-STATES | - |
dc.title | Serum n-6 fatty acids and lipoprotein subclasses in middle-aged men: the population-based cross-sectional ERA-JUMP Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choo, Jina | - |
dc.contributor.affiliatedAuthor | Shin, Chol | - |
dc.identifier.doi | 10.3945/ajcn.2009.28500 | - |
dc.identifier.scopusid | 2-s2.0-77951940099 | - |
dc.identifier.wosid | 000276845100009 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF CLINICAL NUTRITION, v.91, no.5, pp.1195 - 1203 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF CLINICAL NUTRITION | - |
dc.citation.title | AMERICAN JOURNAL OF CLINICAL NUTRITION | - |
dc.citation.volume | 91 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1195 | - |
dc.citation.endPage | 1203 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | CORONARY-HEART-DISEASE | - |
dc.subject.keywordPlus | MAGNETIC-RESONANCE-SPECTROSCOPY | - |
dc.subject.keywordPlus | LOW-DENSITY-LIPOPROTEIN | - |
dc.subject.keywordPlus | DIETARY LINOLEIC-ACID | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | PARTICLE SUBCLASSES | - |
dc.subject.keywordPlus | POLYUNSATURATED FAT | - |
dc.subject.keywordPlus | ARACHIDONIC-ACID | - |
dc.subject.keywordPlus | UNITED-STATES | - |
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